Peng Tzu-Yu, Tsai Pei-Yun, Chen May-Show, Mine Yuichi, Wu Shan-Hua, Chen Chin-Yi, Lin Dan-Jae, Lin Chung-Kwei
School of Dentistry, College of Dentistry, China Medical University, Taichung 404, Taiwan.
Research Center of Digital Oral Science and Technology, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan.
Polymers (Basel). 2021 Feb 18;13(4):618. doi: 10.3390/polym13040618.
Mesoporous bioactive glass (MBG) has a high specific surface area, promoting the reaction area, thereby improving the bioactivity; thus, MBG is currently gaining popularity in the biomaterial field. Spray pyrolysis (SP) is a one-pot process that has the advantages of shorter process time and better particle bioactivity, therefore, MBG was prepared by SP process with various polyethylene glycol (PEG, molecular weight ranged from 2000-12,000) and acid (HCl and CHCOOH) additions. In vitro bioactivity and mesoporous properties of the so-obtained MBG were investigated. The experimental results showed that all the MBG exhibited amorphous and mesoporous structure. Increasing the molecular weight of PEG can improve the mesoporous structure and bioactivity of MBG. Whereas optimized MBG was prepared with suitable concentration of PEG and CHCOOH. In the present work, MBG synthesized via spray pyrolysis by adding 5 g of PEG with a molecular weight of 12,000 and 50 mL of CHCOOH exhibited the best in vitro bioactivity and mesoporous structure.
介孔生物活性玻璃（MBG）具有较高的比表面积，可促进反应面积，从而提高生物活性；因此，MBG目前在生物材料领域越来越受欢迎。喷雾热解（SP）是一种一步法工艺，具有工艺时间短和颗粒生物活性更好的优点，因此，通过SP工艺制备了添加各种聚乙二醇（PEG，分子量范围为2000 - 12000）和酸（HCl和CHCOOH）的MBG。对所得MBG的体外生物活性和介孔性能进行了研究。实验结果表明，所有MBG均呈现无定形和介孔结构。增加PEG的分子量可改善MBG的介孔结构和生物活性。而通过合适浓度的PEG和CHCOOH制备了优化的MBG。在本研究中，通过添加5 g分子量为12000的PEG和50 mL CHCOOH经喷雾热解合成的MBG表现出最佳的体外生物活性和介孔结构。
