Lao Thuan Duc, Le Thuy Ai Huyen
Faculty of Biotechnology, Ho Chi Minh City Open University, Ho Chi Minh City 700000, Vietnam.
Diagnostics (Basel). 2021 Feb 28;11(3):412. doi: 10.3390/diagnostics11030412.
The abnormal expression of circulating miRNAs (c-miRNAs) has become an emerging field in the development of miRNAs-based diagnostic and therapeutic tools for human diseases, including osteoarthritis (OA). OA is the most common form of arthritis leading to disability and a major socioeconomic burden. The abnormal expression of miRNAs plays important roles in the pathogenesis of OA. Unraveling the role of miRNAs in the pathogenesis of OA will throw light on the potential for the development of miRNAs-based diagnostic and therapeutic tools for OA. This article reviews and highlights recent advances in the study of miRNAs in OA, with specific demonstration of the functions of miRNA, especially c-miRNA, in OA pathogenesis as well as its potential implication in the treatment of OA. Based on a systematic literature search using online databases, we figured out the following main points: (1) the integrative systematic review of c-mRNAs and its target genes related to OA pathogenesis; (2) the potential use of c-miRNAs for OA diagnosis purposes as potential biomarkers; and (3) for therapeutic purposes, and we also highlight certain remedies that regulate microRNA expression based on its target genes.
循环微RNA（c-miRNAs）的异常表达已成为基于微RNA开发人类疾病（包括骨关节炎，OA）诊断和治疗工具这一新兴领域的研究内容。OA是导致残疾的最常见关节炎形式，也是一项重大的社会经济负担。微RNA的异常表达在OA发病机制中起重要作用。阐明微RNA在OA发病机制中的作用将为基于微RNA开发OA诊断和治疗工具的潜力提供线索。本文综述并强调了OA中微RNA研究的最新进展，具体阐述了微RNA，尤其是c-miRNA在OA发病机制中的功能及其在OA治疗中的潜在意义。基于使用在线数据库进行的系统文献检索，我们梳理出以下要点：（1）对与OA发病机制相关的c-信使核糖核酸及其靶基因进行综合系统评价；（2）c-miRNAs作为潜在生物标志物在OA诊断中的潜在用途；（3）用于治疗目的，我们还强调了基于其靶基因调节微小RNA表达的某些疗法。
