Balança Baptiste, Desmurs Laurent, Grelier Jérémy, Perret-Liaudet Armand, Lukaszewicz Anne-Claire
Department of Neurological Anesthesiology and Intensive Care Medicine, Hospices Civils de Lyon, Hôpital Pierre Wertheimer, 69500 Bron, France.
Team TIGER, Lyon Neuroscience Research Centre, Inserm U1028, CNRS UMR 5292, 69500 Bron, France.
Int J Mol Sci. 2021 Feb 28;22(5):2439. doi: 10.3390/ijms22052439.
Early or primary injury due to brain aggression, such as mechanical trauma, hemorrhage or is-chemia, triggers the release of damage-associated molecular patterns (DAMPs) in the extracellular space. Some DAMPs, such as S100B, participate in the regulation of cell growth and survival but may also trigger cellular damage as their concentration increases in the extracellular space. When DAMPs bind to pattern-recognition receptors, such as the receptor of advanced glycation end-products (RAGE), they lead to non-infectious inflammation that will contribute to necrotic cell clearance but may also worsen brain injury. In this narrative review, we describe the role and ki-netics of DAMPs and RAGE at the acute phase of brain injury. We searched the MEDLINE database for "DAMPs" or "RAGE" or "S100B" and "traumatic brain injury" or "subarachnoid hemorrhage" or "stroke". We selected original articles reporting data on acute brain injury pathophysiology, from which we describe DAMPs release and clearance upon acute brain injury, and the implication of RAGE in the development of brain injury. We will also discuss the clinical strategies that emerge from this overview in terms of biomarkers and therapeutic perspectives.
由脑部侵害导致的早期或原发性损伤，如机械性创伤、出血或缺血，会触发细胞外空间中损伤相关分子模式（DAMPs）的释放。一些DAMPs，如S100B，参与细胞生长和存活的调节，但随着其在细胞外空间浓度的增加，也可能引发细胞损伤。当DAMPs与模式识别受体结合，如晚期糖基化终产物受体（RAGE）时，它们会导致非感染性炎症，这将有助于坏死细胞的清除，但也可能加重脑损伤。在这篇叙述性综述中，我们描述了DAMPs和RAGE在脑损伤急性期的作用和动力学。我们在MEDLINE数据库中搜索了“DAMPs”或“RAGE”或“S100B”以及“创伤性脑损伤”或“蛛网膜下腔出血”或“中风”。我们选择了报告急性脑损伤病理生理学数据的原始文章，从中我们描述了急性脑损伤时DAMPs的释放和清除，以及RAGE在脑损伤发展中的作用。我们还将从生物标志物和治疗前景的角度讨论从这一概述中得出的临床策略。
