微生物跨界生物膜与新型治疗策略的探索
Microbial Interkingdom Biofilms and the Quest for Novel Therapeutic Strategies.
作者信息
Van Dyck Katrien, Pinto Rita M, Pully Durgasruthi, Van Dijck Patrick
机构信息
Laboratory of Molecular Cell Biology, Institute of Botany and Microbiology, Department of Biology, KU Leuven, 3001 Leuven, Belgium.
VIB-KU Leuven Center for Microbiology, 3001 Leuven, Belgium.
出版信息
Microorganisms. 2021 Feb 17;9(2):412. doi: 10.3390/microorganisms9020412.
Abstract
Fungal and bacterial species interact with each other within polymicrobial biofilm communities in various niches of the human body. Interactions between these species can greatly affect human health and disease. Diseases caused by polymicrobial biofilms pose a major challenge in clinical settings because of their enhanced virulence and increased drug tolerance. Therefore, different approaches are being explored to treat fungal-bacterial biofilm infections. This review focuses on the main mechanisms involved in polymicrobial drug tolerance and the implications of the polymicrobial nature for the therapeutic treatment by highlighting clinically relevant fungal-bacterial interactions. Furthermore, innovative treatment strategies which specifically target polymicrobial biofilms are discussed.
摘要
真菌和细菌物种在人体各个生态位的多微生物生物膜群落中相互作用。这些物种之间的相互作用会极大地影响人类健康和疾病。由多微生物生物膜引起的疾病在临床环境中构成了重大挑战，因为它们具有更强的毒力和更高的耐药性。因此，人们正在探索不同的方法来治疗真菌 - 细菌生物膜感染。本综述重点关注多微生物耐药性的主要机制以及多微生物性质对治疗的影响，通过突出临床相关的真菌 - 细菌相互作用来进行阐述。此外，还讨论了专门针对多微生物生物膜的创新治疗策略。
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