Reichert Stefan, Schulz Susanne, Friebe Lisa, Kohnert Michael, Grollmitz Julia, Schaller Hans-Günter, Hofmann Britt
Department of Operative Dentistry and Periodontology, Martin-Luther-University Halle-Wittenberg, 06112 Halle (Saale), Germany.
Department of Cardiac Surgery, Mid-German Heart Centre of the University Hospital, 06120 Halle (Saale), Germany.
J Clin Med. 2021 Feb 17;10(4):818. doi: 10.3390/jcm10040818.
Periodontitis is a risk factor for atherosclerosis and coronary vascular disease (CVD). This research evaluated the relationship between periodontal conditions and postoperative outcome in patients who underwent coronary artery bypass grafting (CABG). A total of 101 patients with CVD (age 69 years, 88.1% males) and the necessity of CABG surgery were included. Periodontal diagnosis was made according to the guidelines of the Centers for Disease Control and Prevention (CDC, 2007). Additionally, periodontal epithelial surface area (PESA) and periodontal inflamed surface area (PISA) were determined. Multivariate survival analyses were carried out after a one-year follow-up period with Cox regression. All study subjects suffered from periodontitis (28.7% moderate, 71.3% severe). During the follow-up period, 14 patients (13.9%) experienced a new cardiovascular event (11 with angina pectoris, 2 with cardiac decompensation, and 1 with cardiac death). Severe periodontitis was not significant associated with the incidence of new events (adjusted hazard ratio, HR = 2.6; = 0.199). Other risk factors for new events were pre-existing peripheral arterial disease (adjusted HR = 4.8, = 0.030) and a history of myocardial infarction (HR = 6.1, = 0.002). Periodontitis was not found to be an independent risk factor for the incidence of new cardiovascular events after CABG surgery.
牙周炎是动脉粥样硬化和冠状动脉血管疾病（CVD）的一个风险因素。本研究评估了接受冠状动脉旁路移植术（CABG）患者的牙周状况与术后结果之间的关系。总共纳入了101例患有CVD（年龄69岁，男性占88.1%）且有必要进行CABG手术的患者。根据疾病控制与预防中心（CDC，2007年）的指南进行牙周诊断。此外，还测定了牙周上皮表面积（PESA）和牙周炎症表面积（PISA）。在为期一年的随访期后，采用Cox回归进行多变量生存分析。所有研究对象均患有牙周炎（28.7%为中度，71.3%为重度）。在随访期间，14例患者（13.9%）发生了新的心血管事件（11例心绞痛，2例心脏代偿失调，1例心源性死亡）。重度牙周炎与新事件的发生率无显著相关性（调整后的风险比，HR = 2.6；P = 0.199）。新事件的其他风险因素包括既往存在的外周动脉疾病（调整后的HR = 4.8，P = 0.030）和心肌梗死病史（HR = 6.1，P = 0.002）。未发现牙周炎是CABG手术后新的心血管事件发生率的独立风险因素。
