丹尼尔·K·伊努耶药学院文稿：痛风与高尿酸血症流行病学视角
The Daniel K. Inouye College of Pharmacy Scripts: Perspectives on the Epidemiology of Gout and Hyperuricemia.
作者信息
Roman Youssef M
机构信息
Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, Hilo, HI.
出版信息
Hawaii J Med Public Health. 2019 Feb;78(2):71-76.
Abstract
Gout is the most common inflammatory arthritic condition affecting more men than women. Hyperuricemia and the deposition of urate crystals into the joints are the hallmarks of gout. The prevalence of gout and hyperuricemia is rising in the United States and world-wide possibly due to the aging population, comorbidities, and other lifestyle factors. Gout and serum uric acid (SUA) levels are highly heritable, underscoring the role of genetics on disease risk and possibly the racial disparities in gout prevalence. However, high consumption of high fructose corn syrup, alcohol, select dietary lifestyles, and use of diuretics are associated with higher SUA levels and increased risk for developing gout. Adopting healthy diet and lifestyle modifications can lower SUA levels. Nonetheless, diet-based approaches for the management of gout should remain a secondary approach to urate lowering therapy.
摘要
痛风是最常见的炎性关节炎病症，男性患者多于女性。高尿酸血症以及尿酸盐结晶在关节中的沉积是痛风的标志。在美国及全球范围内，痛风和高尿酸血症的患病率都在上升，这可能归因于人口老龄化、合并症以及其他生活方式因素。痛风和血清尿酸（SUA）水平具有高度遗传性，这凸显了遗传因素在疾病风险中的作用，也可能解释了痛风患病率的种族差异。然而，高果糖玉米糖浆、酒精的大量摄入、特定的饮食习惯以及利尿剂的使用都与较高的SUA水平和痛风发病风险增加有关。采取健康的饮食和生活方式调整可以降低SUA水平。尽管如此，基于饮食的痛风管理方法仍应作为降低尿酸治疗的辅助方法。
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