Sandler R S, Jordan M C, Kupper L L
Department of Medicine, University of North Carolina, Chapel Hill 27599-7080.
J Clin Epidemiol. 1988;41(5):451-8. doi: 10.1016/0895-4356(88)90046-7.
Current Crohn's disease activity indices are not suitable for survey research because they rely on information from the laboratory or physical examination. We used data from a multicenter controlled trial of adjuvant sulfasalazine to develop an index of Crohn's disease activity based on information which could be obtained exclusively by interview. The study population consisted of 89 actively symptomatic patients seen on 1082 occasions in eight medical centers. Multiple regression analyses identified three variables which predicted the ratings of physicians: stool frequency, abdominal pain and sense of well-being. The new index correlated very well (r = 0.87, p less than 0.001) with the Crohn's Disease Activity Index from which it was derived. The index may be used in epidemiologic studies to accurately place patients into quartiles of disease severity which correspond to similar quartiles of the CDAI.
目前的克罗恩病活动指数不适合用于调查研究，因为它们依赖实验室或体格检查的信息。我们利用一项辅助性柳氮磺胺吡啶多中心对照试验的数据，基于仅通过访谈即可获得的信息，制定了一个克罗恩病活动指数。研究人群包括89名有明显症状的患者，他们在8个医疗中心共接受了1082次检查。多元回归分析确定了三个预测医生评分的变量：大便频率、腹痛和幸福感。这个新指数与推导它所依据的克罗恩病活动指数相关性非常好（r = 0.87，p < 0.001）。该指数可用于流行病学研究，以准确地将患者分为疾病严重程度的四分位数，这些四分位数与克罗恩病活动指数（CDAI）的类似四分位数相对应。
