Department of Internal Medicine, Diabetology and Nephrology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland.
Int J Environ Res Public Health. 2021 Feb 23;18(4):2202. doi: 10.3390/ijerph18042202.
Fractalkine () is a chemokine that plays a significant role in inflammation, one of the pathophysiological processes underlying end-stage renal disease (ESRD). Genetic factors are significantly involved in cytokine expression and have been studied as potential risk factors for chronic kidney disease (CKD). : We aimed to elucidate the association of gene polymorphisms rs3732378 and rs3732379 with the levels of , receptor (), as well as C-reactive protein (CRP). : We enrolled 198 participants, including 106 patients with ESRD and 92 controls. Peripheral blood samples were collected from each patient for genetic (rs3732378 and rs3732379 polymorphisms) and immunoenzymatic (fractalkine, , CRP) tests. : and CRP levels were higher in patients with ESRD than in controls ( < 0.05). Fractalkine levels were significantly higher in ESRD patients who were homozygous for the G allele of the rs3732378 polymorphism and for the C allele of the rs3732379 polymorphism than in homozygous controls. Moreover, carriers of these alleles among patients with ESRD had significantly higher levels than controls. : The G allele of the rs3732378 polymorphism and the C allele of the rs3732379 polymorphism of the gene are associated with higher and levels. Our study suggests that gene polymorphisms could be potentially involved in the pathogenesis of ESRD, but the study needs to be replicated in a larger population with a longitudinal follow-up study. Identification of genetic factors associated with inflammation in ESRD may contribute to the development of targeted gene therapies in the future.
趋化因子（）在炎症中起着重要作用，而炎症是终末期肾病（）的病理生理过程之一。遗传因素在细胞因子表达中起着重要作用，并被研究为慢性肾病（）的潜在危险因素。：我们旨在阐明基因多态性与水平、受体（）以及 C 反应蛋白（）之间的关联。：我们纳入了 198 名参与者，包括 106 名终末期肾病患者和 92 名对照。从每位患者采集外周血样进行遗传（rs3732378 和 rs3732379 多态性）和免疫酶（趋化因子、、CRP）检测。：与对照组相比，终末期肾病患者的和 CRP 水平更高（<0.05）。与 rs3732378 多态性的 GG 纯合子和 rs3732379 多态性的 CC 纯合子相比，rs3732378 多态性的 GG 纯合子和 rs3732379 多态性的 CC 纯合子的患者的趋化因子水平明显更高。此外，与对照组相比，这些等位基因携带者的水平明显更高。：基因 rs3732378 多态性的 G 等位基因和 rs3732379 多态性的 C 等位基因与水平升高相关。我们的研究表明，基因多态性可能与终末期肾病的发病机制有关，但需要在更大的人群中进行复制，并进行纵向随访研究。鉴定与终末期肾病炎症相关的遗传因素可能有助于未来开发针对基因的治疗方法。
