Tse Ryan Tsz-Hei, Zhao Hongda, Wong Christine Yim-Ping, Cheng Carol Ka-Lo, Kong Angel Wing-Yan, Peng Qiang, Chiu Peter Ka-Fung, Ng Chi-Fai, Teoh Jeremy Yuen-Chun
S.H. Ho Urology Centre, Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China.
Diagnostics (Basel). 2021 Feb 14;11(2):306. doi: 10.3390/diagnostics11020306.
Urinary bladder cancer is a common urological cancer. Although flexible cystoscopy is widely employed in bladder cancer detection, it is expensive, invasive, and uncomfortable to the patients. Recently, urinary cell-free DNA (ucfDNA) isolated from urine supernatant has been shown to have great potential in bladder cancer detection and surveillance. Molecular features, such as integrity and concentration of ucfDNA, have been shown to be useful for differentiating bladder cancer patients from healthy controls. Besides, bladder cancer also exhibits unique genetic features that can be identified from sequencing and expression of ucfDNA. Apart from bladder cancer detection, ucfDNA is also useful for molecular classification. For example, ucfDNA exhibits significant differences, both molecularly and genetically, in non-muscle-invasive and muscle-invasive bladder cancers. There is no doubt that ucfDNA is a very promising tool for future applications in the field of bladder cancer.
膀胱癌是一种常见的泌尿系统癌症。尽管软性膀胱镜检查在膀胱癌检测中被广泛应用，但它成本高昂、具有侵入性，且会给患者带来不适。最近，从尿液上清液中分离出的游离尿DNA（ucfDNA）已显示出在膀胱癌检测和监测方面具有巨大潜力。ucfDNA的分子特征，如完整性和浓度，已被证明有助于区分膀胱癌患者和健康对照。此外，膀胱癌还表现出独特的遗传特征，可从ucfDNA的测序和表达中识别出来。除了膀胱癌检测，ucfDNA在分子分类方面也很有用。例如，ucfDNA在非肌层浸润性和肌层浸润性膀胱癌中，在分子和基因方面都表现出显著差异。毫无疑问，ucfDNA是未来在膀胱癌领域应用中非常有前景的工具。
