Department of Oral and Maxillo-Facial Sciences, Sapienza University of Rome, 00161 Roma, Italy.
Department of Radiological Oncological and Pathological Sciences, Sapienza University of Rome, 00161 Roma, Italy.
Int J Environ Res Public Health. 2021 Feb 14;18(4):1851. doi: 10.3390/ijerph18041851.
Medication-related osteonecrosis of the jaw (MRONJ) is an adverse event associated with antiresorptive and antiangiogenic drugs. The use of these drugs in the treatment of cancer patients with bone metastasis is necessary and standardized in the literature. A multidisciplinary approach for the patient's management is strongly recommended. Therefore, it should be necessary to integrate the path of these subjects with a dedicated dental screening in order to first assess the individual risk of developing a MRONJ, and then to plan dental treatments and oral hygiene sessions, and finally to schedule a follow-up to intercept and treat early osteonecrosis. The aim of this manuscript is to propose a new simple medical report to evaluate patients affected by metastatic bone cancer in order to reduce the risk of developing MRONJ.
药物相关性下颌骨坏死（MRONJ）是一种与抗吸收和抗血管生成药物相关的不良事件。这些药物在治疗伴有骨转移的癌症患者中的使用在文献中是必要的和标准化的。强烈推荐对患者进行多学科管理。因此，应该有必要将这些患者的路径与专门的牙科筛查相结合，以便首先评估个体发生 MRONJ 的风险，然后计划牙科治疗和口腔卫生治疗，最后安排随访以截获和治疗早期骨坏死。本文的目的是提出一种新的简单医疗报告来评估患有转移性骨癌的患者，以降低发生 MRONJ 的风险。
