来自八放珊瑚的西松烷型二萜类化合物（冯·马伦泽勒，1886年）。

Cembranoids from Octocoral (von Marenzeller, 1886).

作者信息

Yeh Yao-Tsung, Lin Sung-Chun, Lee Gene-Hsiang, Wen Zhi-Hong, Hwang Tsong-Long, Wu Yu-Jen, Chen Jih-Jung, Fang Lee-Shing, Yuan Mei-Kang, Sung Ping-Jyun

机构信息

Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944401, Taiwan.

National Museum of Marine Biology and Aquarium, Pingtung 944401, Taiwan.

出版信息

Mar Drugs. 2021 Feb 27;19(3):130. doi: 10.3390/md19030130.

DOI:10.3390/md19030130

PMID:33673526

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7997245/

Abstract

Two cembranoids, including a new compound, lobocrassin I (), as well as a known analogue, lobohedleolide (), were obtained by solvent extraction from octocoral . This study employed a spectroscopic approach to establish the structures of these two cembranoids, and utilized single-crystal X-ray diffraction analysis to determine their absolute configurations. The results of biological activity assays demonstrated that cembranoid exhibited bioactivity against the protein expressions of inducible nitric oxide synthase (iNOS) lipopolysaccharide (LPS)-treated RAW 264.7 mouse macrophage cells.

摘要

通过溶剂萃取法从八放珊瑚中获得了两种西松烷型二萜类化合物，其中包括一种新化合物——环叶粗枝软珊瑚素I（），以及一种已知类似物——叶软珊瑚内酯（）。本研究采用光谱方法确定这两种西松烷型二萜类化合物的结构，并利用单晶X射线衍射分析确定其绝对构型。生物活性测定结果表明，西松烷型二萜类化合物对脂多糖（LPS）处理的RAW 264.7小鼠巨噬细胞中诱导型一氧化氮合酶（iNOS）的蛋白表达具有生物活性。