Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan.
Mar Drugs. 2014 Jan 28;12(2):840-50. doi: 10.3390/md12020840.
New cembranoids, sarcocrassocolides P-R (1-3) and four known compounds (4-7) were isolated from the soft coral Sarcophyton crassocaule. The structures of the metabolites were determined by extensive spectroscopic analysis. Compounds 3-5 and 7 were shown to exhibit cytotoxicity toward a limited panel of cancer cell lines and all compounds 1-7 displayed potent in vitro anti-inflammatory activity in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells by inhibiting the expression of inducible nitric oxide synthase (iNOS) protein. Compound 7 also showed significant activity in reducing the accumulation of cyclooxygenase-2 (COX-2) protein in the same macrophage cells.
从软珊瑚 Sarcophyton crassocaule 中分离得到了新的海鞘烷二萜类化合物 sarcocrassocolides P-R（1-3）和四个已知化合物（4-7）。通过广泛的光谱分析确定了代谢产物的结构。化合物 3-5 和 7 对一组有限的癌细胞系表现出细胞毒性，所有化合物 1-7 均通过抑制诱导型一氧化氮合酶（iNOS）蛋白的表达，在脂多糖（LPS）刺激的 RAW264.7 巨噬细胞中表现出很强的体外抗炎活性。化合物 7 还在减少同一巨噬细胞中环氧合酶-2（COX-2）蛋白积累方面表现出显著的活性。
