Faculdade de Ciências e Tecnologia, Departamento de Química e Farmácia, Universidade do Algarve, Edifício 8, MeditBio, Campus de Gambelas, 8005-139 Faro, Portugal.
Department of Chemistry, Faculty of Sciences and Arts in Balgarn, University of Bisha, Bisha 61922, P.O. BOX 199, Saudi Arabia.
Molecules. 2019 Feb 21;24(4):781. doi: 10.3390/molecules24040781.
This work reviews the new isolated cembranoid derivatives from species of the genera , , and as well as their biological properties, during 2016⁻2018. The compilation permitted to conclude that much more new cembranoid diterpenes were found in the soft corals of the genus than in those belonging to the genera or . Beyond the chemical composition, the biological properties were also reviewed, namely anti-microbial against several Gram-positive and Gram-negative bacteria and fungi, anti-inflammatory and anti-tumoral against several types of cancer cells. In spite of the biological activities detected in almost all samples, there is a remarkable diversity in the results which may be attributed to the chemical variability that needs to be deepened in order to develop new molecules with potential application in medicine.
本工作综述了 2016 年至 2018 年间从属、属和属的物种中分离得到的新的海鞘烷型衍生物及其生物活性。这一综述表明，在属的软珊瑚中发现的新海鞘烷二萜类化合物远比属或属的软珊瑚中多。除了化学成分外，还综述了生物活性，即对几种革兰氏阳性和革兰氏阴性细菌和真菌、抗炎和抗肿瘤对几种类型的癌细胞具有活性。尽管几乎所有样品都检测到了生物活性，但结果存在显著的差异，这可能归因于需要进一步深入研究的化学变异性，以便开发具有潜在医学应用的新分子。
