González Yisett, Torres-Mendoza Daniel, Jones Gillian E, Fernandez Patricia L
Centro de Biología Celular y Molecular de Enfermedades, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Ciudad de Panamá, Panama ; Department of Biotechnology, Acharya Nagarjuna University, Guntur 522510, India.
Department of Biotechnology, Acharya Nagarjuna University, Guntur 522510, India ; Centro de Descubrimiento de Drogas y Biodiversidad, INDICASAT AIP, Ciudad de Panamá, Panama.
Mediators Inflamm. 2015;2015:263543. doi: 10.1155/2015/263543. Epub 2015 Oct 11.
The inflammatory response is a highly regulated process, and its dysregulation can lead to the establishment of chronic inflammation and, in some cases, to death. Inflammation is the cause of several diseases, including rheumatoid arthritis, inflammatory bowel diseases, multiple sclerosis, and asthma. The search for agents inhibiting inflammation is a great challenge as the inflammatory response plays an important role in the defense of the host to infections. Marine invertebrates are exceptional sources of new natural products, and among those diterpenoids secondary metabolites exhibit notable anti-inflammatory properties. Novel anti-inflammatory diterpenoids, exclusively produced by marine organisms, have been identified and synthetic molecules based on those structures have been obtained. The anti-inflammatory activity of marine diterpenoids has been attributed to the inhibition of Nuclear Factor-κB activation and to the modulation of arachidonic acid metabolism. However, more research is necessary to describe the mechanisms of action of these secondary metabolites. This review is a compilation of marine diterpenoids, mainly isolated from corals, which have been described as potential anti-inflammatory molecules.
炎症反应是一个高度受调控的过程，其失调会导致慢性炎症的形成，在某些情况下甚至会导致死亡。炎症是包括类风湿性关节炎、炎症性肠病、多发性硬化症和哮喘在内的多种疾病的病因。由于炎症反应在宿主抵御感染中起着重要作用，寻找抑制炎症的药物是一项巨大挑战。海洋无脊椎动物是新型天然产物的特殊来源，其中二萜类次生代谢产物具有显著的抗炎特性。已经鉴定出仅由海洋生物产生的新型抗炎二萜类化合物，并获得了基于这些结构的合成分子。海洋二萜类化合物的抗炎活性归因于对核因子κB激活的抑制以及对花生四烯酸代谢的调节。然而，需要更多研究来描述这些次生代谢产物的作用机制。本综述汇编了主要从珊瑚中分离出的海洋二萜类化合物，它们被描述为潜在的抗炎分子。
