Kaplan G A, Reynolds P
Human Population Laboratory, California Department of Health Services, Berkeley 94704.
J Behav Med. 1988 Feb;11(1):1-13. doi: 10.1007/BF00846165.
The association between the presence of depressive symptoms and cancer incidence and mortality and mortality from noncancer causes was studied in a population-based cohort of 6848 persons free of cancer who were followed from 1965 to 1982 as part of the Alameda County study. Age-adjusted and multivariate analyses involving over 111,000 person-years of follow-up demonstrated an association between high levels of depressive symptoms at baseline and deaths from noncancer causes but no association with either cancer incidence or cancer mortality. Our analyses suggest the possibility that the presence of previously diagnosed cases of cancer and the inclusion of items which tap somatic problems in depression scales may contribute to differences between these results and others in which depression has been linked to cancer mortality.
在阿拉米达县研究的一部分中，对6848名无癌症人群进行了基于人群的队列研究，以探讨抑郁症状的存在与癌症发病率、死亡率以及非癌症原因死亡率之间的关联。这些人群在1965年至1982年期间接受随访。涉及超过111,000人年随访的年龄调整和多变量分析表明，基线时高水平的抑郁症状与非癌症原因导致的死亡之间存在关联，但与癌症发病率或癌症死亡率均无关联。我们的分析表明，先前诊断出的癌症病例的存在以及抑郁量表中涉及躯体问题的项目的纳入，可能是导致这些结果与其他将抑郁与癌症死亡率联系起来的研究结果存在差异的原因。
