Department of Psychology, Faculty of Science, Memorial University of Newfoundland, St. John's, NL A1B 3X9, Canada.
Department of Psychology, Faculty of Science, Memorial University of Newfoundland, St. John's, NL A1B 3X9, Canada.
Semin Cell Dev Biol. 2021 Aug;116:125-134. doi: 10.1016/j.semcdb.2020.12.010. Epub 2021 Mar 2.
Braak has described the beginnings of Alzheimer's Disease as occurring in the locus coeruleus. Here we review these pretangle stages and relate their expression to recently described normal features of tau biology. We suggest pretangle tau depends on characteristics of locus coeruleus operation that promote tau condensates. We examine the timeline of pretangle and tangle appearance in locus coeruleus. We find catastrophic loss of locus coeruleus neurons is a late event. The strong relationship between locus coeruleus neuron number and human cognition underscores the utility of a focus on locus coeruleus. Promoting locus coeruleus health will benefit normal aging as well as aid in the prevention of dementia. Two animal models offering experimental approaches to understanding the functional change initiated by pretangles in locus coeruleus neurons are discussed.
Braak 描述了阿尔茨海默病的起源发生在蓝斑核。在这里，我们回顾这些预缠结阶段，并将其表达与最近描述的 tau 生物学的正常特征联系起来。我们假设预缠结 tau 取决于促进 tau 凝聚的蓝斑核操作的特征。我们检查了蓝斑核中预缠结和缠结出现的时间线。我们发现蓝斑核神经元的灾难性丧失是一个晚期事件。蓝斑核神经元数量与人类认知之间的强烈关系突出了关注蓝斑核的效用。促进蓝斑核健康将有益于正常衰老，并有助于预防痴呆症。讨论了两种提供实验方法来理解蓝斑核神经元中预缠结引发的功能变化的动物模型。
