Zhang Wen, Fan Meiling, Wang Cunchuan, Mahawar Kamal, Parmar Chetan, Chen Weiju, Yang Wah
School of Nursing, Jinan University, Guangzhou, No.601, Huangpu Avenue West, Guangzhou, Guangdong, China.
Department of Biliary Tract Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Obes Surg. 2021 Jun;31(6):2649-2659. doi: 10.1007/s11695-021-05311-2. Epub 2021 Mar 5.
Hair loss is a common complication after metabolic and bariatric surgery (MBS). There is a lack of published systematic review in the scientific literature on this topic. The aim of this study was to perform a systematic review and meta-analysis on hair loss after MBS in accordance with Preferred Reporting Items for Systematic reviews and Meta-Analysis (PRISMA) guidelines.
PubMed, CINAHL, EMBASE, Web of Science, SCOPUS, and four Chinese databases were searched. Data were pooled using Review Manager 5.3 and Stata 12.0, and subgroups were performed if necessary and feasible.
A total of 18 studies (n = 2538) were included. The pooled results showed that the incidence of hair loss after MBS was 57% (95% CI 42-71%). It decreased with longer follow-up times. Hair loss was significantly more common in younger (mean difference (MD), - 2.45; 95% CI, - 4.26 to - 0.64; p = 0.008) women (OR, 3.87; 95% CI, 0.59 to 17.59; p = 0.08). Serum zinc (standardized mean difference (SMD), - 1.13; 95% CI, - 2.27 to 0.01, p = 0.05), folic acid (SMD = - 0.88, 95% CI - 1.29 to - 0.46, p < 0.0001), and ferritin levels (SMD, - 0.22; 95% CI, - 0.38 to - 0.05; p = 0.01), but not serum iron and vitamin B, were associated with hair loss following MBS.
Hair loss is common after MBS especially in younger women, and those with low serum levels of zinc, folic acid, and ferritin. Prospective studies on larger cohorts are needed.
脱发是代谢和减重手术后的常见并发症。关于这一主题，科学文献中缺乏已发表的系统评价。本研究的目的是按照系统评价和Meta分析的首选报告项目（PRISMA）指南，对代谢和减重手术后的脱发情况进行系统评价和Meta分析。
检索了PubMed、CINAHL、EMBASE、科学网、Scopus以及四个中文数据库。使用Review Manager 5.3和Stata 12.0对数据进行汇总，必要且可行时进行亚组分析。
共纳入18项研究（n = 2538）。汇总结果显示，代谢和减重手术后脱发的发生率为57%（95%置信区间42 - 71%）。随着随访时间延长，脱发发生率降低。脱发在年轻女性中更为常见（平均差（MD），-2.45；95%置信区间，-4.26至-0.64；p = 0.008）（比值比（OR），3.87；95%置信区间，0.59至17.59；p = 0.08）。血清锌（标准化平均差（SMD），-1.13；95%置信区间，-2.27至0.01，p = 0.05）、叶酸（SMD = -0.88，95%置信区间-1.29至-0.46，p < 0.0001）和铁蛋白水平（SMD，-0.22；95%置信区间，-0.38至-0.05；p = 0.01）与代谢和减重手术后的脱发有关，但血清铁和维生素B与脱发无关。
代谢和减重手术后脱发很常见，尤其是在年轻女性以及血清锌、叶酸和铁蛋白水平较低的人群中。需要对更大队列进行前瞻性研究。
