Department of Respiratory and Critical Care Medicine, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jingwu Road 324#, Jinan, 250021, Shandong, China.
Department of Respiratory and Critical Care Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.
Mol Biol Rep. 2021 Mar;48(3):2741-2749. doi: 10.1007/s11033-021-06250-y. Epub 2021 Mar 6.
Beta-2-adrenergic receptor is a member of the G protein-coupled receptor superfamily, which is highly expressed in most malignancies. There is increasing evidence showing that beta-2-adrenergic receptors are associated with carcinogenesis, proliferation, immune regulation, invasion, angiogenesis, clinical prognosis and treatment resistance in malignancies. Polymorphisms of the ADRB2 gene have been confirmed to be associated with transcriptional activity, mRNA translation, and beta-2-adrenergic receptor expression and sensitivity. This review discusses clinically relevant examples of single nucleotide polymorphisms of ADRB2 in malignancies and the effects of these polymorphisms on cancer susceptibility, prognosis and treatment response of cancer patients.
β2-肾上腺素能受体是 G 蛋白偶联受体超家族的成员，在大多数恶性肿瘤中高度表达。越来越多的证据表明，β2-肾上腺素能受体与恶性肿瘤的发生、增殖、免疫调节、侵袭、血管生成、临床预后和治疗耐药性有关。ADRB2 基因的多态性已被证实与转录活性、mRNA 翻译以及β2-肾上腺素能受体表达和敏感性有关。本综述讨论了 ADRB2 单核苷酸多态性在恶性肿瘤中的临床相关实例，以及这些多态性对癌症易感性、癌症患者预后和治疗反应的影响。
