Huang X E, Hamajima N, Saito T, Matsuo K, Mizutani M, Iwata H, Iwase T, Miura S, Mizuno T, Tokudome S, Tajima K
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan.
Breast Cancer Res. 2001;3(4):264-9. doi: 10.1186/bcr304. Epub 2001 Apr 26.
The involvement of beta2-adrenergic receptor (ADRB2) and beta3-adrenergic receptor (ADRB3) in both adipocyte lipolysis and thermogenic activity suggests that polymorphisms in the encoding genes might be linked with interindividual variation in obesity, an important risk factor for postmenopausal breast cancer. In order to examine the hypothesis that genetic variations in ADRB2 and ADRB3 represent interindividual susceptibility factors for obesity and breast cancer, we conducted a hospital-based, case-control study in the Aichi Cancer Center, Japan.
A self-administered questionnaire was given to 200 breast cancer patients and 182 control individuals, and pertinent information on lifestyle, family history and reproduction was collected. ADRB2 and ADRB3 genotypes were determined by polymerase chain reaction (PCR) restriction fragment length polymorphism assessment.
Twenty-five (12.4%) breast cancer patients and 32 (17.6%) control individuals were found to bear a glutamic acid (Glu) allele for the ADRB2 gene (odds ratio [OR] 0.67, 95% confidence interval [CI] 0.38-1.18), and 60 (30.0%) breast cancer patients and 61 (33.5%) control individuals were found to bear an Arg allele for the ADRB3 gene (OR 0.85, 95% CI 0.55-1.31). A significantly lower risk was observed in those who carried the Glu ADRB2 allele and who reported first childbirth when they were younger than 25 years (OR 0.35; 95% CI 0.13-0.99).
A potential association may exist between risk of breast cancer and polymorphisms in the ADRB2 and ADRB3 genes; further studies in larger samples and/or in different ethnic groups are warranted to investigate this potential association.
β2-肾上腺素能受体（ADRB2）和β3-肾上腺素能受体（ADRB3）参与脂肪细胞脂解和产热活动，这表明编码基因中的多态性可能与肥胖的个体差异有关，肥胖是绝经后乳腺癌的一个重要危险因素。为了检验ADRB2和ADRB3基因变异代表肥胖和乳腺癌个体易感性因素这一假设，我们在日本爱知癌症中心进行了一项基于医院的病例对照研究。
向200例乳腺癌患者和182例对照个体发放了一份自填式问卷，并收集了有关生活方式、家族史和生育情况的相关信息。通过聚合酶链反应（PCR）限制性片段长度多态性评估确定ADRB2和ADRB3基因型。
发现25例（12.4%）乳腺癌患者和32例（17.6%）对照个体携带ADRB2基因的谷氨酸（Glu）等位基因（比值比[OR]0.67，95%置信区间[CI]0.38 - 1.18），60例（30.0%）乳腺癌患者和61例（33.5%）对照个体携带ADRB3基因的精氨酸（Arg）等位基因（OR 0.85，95% CI 0.55 - 1.31）。在携带Glu ADRB2等位基因且报告首次生育年龄小于25岁的人群中观察到显著较低的风险（OR 0.35；95% CI 0.13 - 0.99）。
乳腺癌风险与ADRB2和ADRB3基因多态性之间可能存在潜在关联；有必要在更大样本和/或不同种族群体中进行进一步研究以调查这种潜在关联。
