Department of Gastroenterology and Hepatology, University of Connecticut Health Center, Farmington, Connecticut, USA.
J Dig Dis. 2021 Apr;22(4):214-221. doi: 10.1111/1751-2980.12980. Epub 2021 Mar 29.
Adiponectin is an adipokine that has anti-steatotic, anti-inflammatory and anti-fibrotic effects. The impact of these different activities impact on the development and progression of non-alcoholic fatty liver disease (NAFLD) is not well understood. The aim of this study was to evaluate both liver and serum adiponectin levels in patients with and without NAFLD and determine any clinical correlations.
Liver tissue and serum samples were collected from patients undergoing liver biopsy between April 2014 and July 2020, and categorized based on histopathological diagnosis into hepatic steatosis (HS), non-alcoholic steatohepatitis (NASH), and hepatitis control (HC). A Luminex xMAP assay was performed on both liver and serum samples to measure adiponectin levels. Statistical analysis compared liver adiponectin (LA) and serum adiponectin (SA) levels between groups.
A total of 48 participants were included in the analysis. The mean LA level was lowest in the HS group, followed by the NASH group and the HC group (P = 0.036). The mean SA level was 3.61 μg/mL for the NAFLD group and was significantly lower than that in the HC (7.51 μg/mL; P = 0.001).
Adiponectin levels are lower in NAFLD compared to HC in both serum and liver tissue. LA levels in patients with HS were significantly lower than in both the NASH and HC groups, suggesting that adiponectin is related to inflammation in the liver and probably reflects its role in the pathogenesis of NAFLD.
脂联素是一种脂肪因子，具有抗脂肪变性、抗炎和抗纤维化作用。这些不同活性对非酒精性脂肪性肝病（NAFLD）的发展和进展的影响尚不清楚。本研究旨在评估有和无 NAFLD 的患者的肝组织和血清脂联素水平，并确定任何临床相关性。
收集 2014 年 4 月至 2020 年 7 月期间接受肝活检的患者的肝组织和血清样本，并根据组织病理学诊断分为肝脂肪变性（HS）、非酒精性脂肪性肝炎（NASH）和肝炎对照组（HC）。对肝和血清样本进行 Luminex xMAP 检测，以测量脂联素水平。统计分析比较各组间肝脂联素（LA）和血清脂联素（SA）水平。
共纳入 48 名参与者进行分析。LA 水平在 HS 组最低，其次是 NASH 组和 HC 组（P = 0.036）。NAFLD 组的平均 SA 水平为 3.61μg/mL，明显低于 HC 组（7.51μg/mL；P = 0.001）。
与 HC 相比，NAFLD 患者的血清和肝组织中的脂联素水平均较低。HS 患者的 LA 水平明显低于 NASH 和 HC 组，提示脂联素与肝脏炎症有关，可能反映了其在 NAFLD 发病机制中的作用。
