Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Department of Echocardiography, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Exp Neurol. 2021 Jun;340:113684. doi: 10.1016/j.expneurol.2021.113684. Epub 2021 Mar 5.
Stroke is a leading cause of mortality and morbidity worldwide. Understanding the underlying mechanisms is important for developing effective therapies for treating stroke. Autophagy is a self-eating cellular catabolic pathway, which plays a crucial homeostatic role in the regulation of cell survival. Increasing evidence shows that autophagy, observed in various cell types, plays a critical role in brain pathology after ischemic stroke. Therefore, the regulation of autophagy can be a potential target for ischemic stroke treatment. In the present review, we summarize the recent progress that research has made regarding autophagy and ischemic stroke, including common signaling pathways, the role of autophagic subtypes (e.g. mitophagy, pexophagy, aggrephagy, endoplasmic reticulum-phagy, and lipophagy) in ischemic stroke, as well as the current methods for autophagy detection and potential therapeutic strategy.
中风是全球范围内导致死亡和发病的主要原因之一。了解其潜在机制对于开发治疗中风的有效疗法至关重要。自噬是一种自我吞噬的细胞分解代谢途径，在调节细胞存活方面发挥着重要的动态平衡作用。越来越多的证据表明，在各种细胞类型中观察到的自噬在缺血性中风后的脑病理中起着关键作用。因此，自噬的调节可能是缺血性中风治疗的一个潜在靶点。在本综述中，我们总结了自噬与缺血性中风研究的最新进展，包括常见的信号通路、自噬亚型（如线粒体自噬、过氧化物酶体自噬、聚集体自噬、内质网自噬和脂自噬）在缺血性中风中的作用，以及自噬检测的当前方法和潜在的治疗策略。
