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COVID-19 疫苗诱导的辐射回忆现象。

COVID-19 Vaccine-Induced Radiation Recall Phenomenon.

机构信息

Department of Radiation Oncology, Division of Oncology, Tel-Aviv Medical Center, affiliated with Sackler School of Medicine, Tel-Aviv University.

Department of Radiation Oncology, Division of Oncology, Tel-Aviv Medical Center, affiliated with Sackler School of Medicine, Tel-Aviv University.

出版信息

Int J Radiat Oncol Biol Phys. 2021 Jul 15;110(4):957-961. doi: 10.1016/j.ijrobp.2021.02.048. Epub 2021 Mar 4.

DOI:10.1016/j.ijrobp.2021.02.048
PMID:33677050
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7930806/
Abstract

Radiation recall phenomenon (RRP) is an uncommon, late occurring, acute inflammatory skin reaction that emerges in localized areas coincident with previously irradiated radiation therapy (RT) treatment fields. RRP has been known to be triggered by a number of chemotherapy agents. To the best of our knowledge, this report is the first description of RRP after administration of the Pfizer-BioNTech vaccine for COVID-19, or any other currently available vaccine against COVID-19. Acute skin reactions were observed in 2 RT patients with differing timelines of RT and vaccinations. In both cases however, the RRP presented within days of the patient receiving the second dose of vaccine. For each RT course, the treatment planning dosimetry of the radiation fields was compared with the area of the observable RRP. RRP developed within the borders of treatment fields where prescription dose constraints were prioritized over skin sparing. Our observation is currently limited to 2 patients. The actual incidence of RRP in conjunction with Pfizer-BioNTech vaccine or any other vaccine against COVID-19 is unknown. For patients with cancer being treated with radiation with significant dose to skin, consideration should be given to the probability of RRP side effects from vaccinations against COVID-19.

摘要

辐射召回现象（RRP）是一种不常见的、迟发性、急性炎症性皮肤反应，出现在与先前接受过放射治疗（RT）治疗区域相一致的局部区域。RRP 已知可由多种化疗药物引发。据我们所知，这是首次在接种辉瑞-生物技术公司的 COVID-19 疫苗或任何其他目前可用的 COVID-19 疫苗后出现 RRP 的报告。2 名接受 RT 治疗的患者出现了急性皮肤反应，他们的 RT 和疫苗接种时间不同。然而，在这两种情况下，RRP 均在患者接受第二剂疫苗后的几天内出现。对于每个 RT 疗程，将辐射野的治疗计划剂量与可观察到的 RRP 区域进行比较。RRP 出现在处方剂量限制优先于皮肤保护的治疗野边界内。我们的观察目前仅限于 2 名患者。目前尚不清楚 Pfizer-BioNTech 疫苗或任何其他 COVID-19 疫苗与 RRP 的实际发生率。对于正在接受皮肤大剂量放射治疗的癌症患者，应考虑 COVID-19 疫苗接种引起 RRP 副作用的可能性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/576d/7930806/3827973c6408/gr6_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/576d/7930806/56c1b8b8c814/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/576d/7930806/08638a372327/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/576d/7930806/621235257408/gr3_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/576d/7930806/66c8020b476a/gr4_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/576d/7930806/009754c79895/gr5_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/576d/7930806/3827973c6408/gr6_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/576d/7930806/56c1b8b8c814/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/576d/7930806/08638a372327/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/576d/7930806/621235257408/gr3_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/576d/7930806/66c8020b476a/gr4_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/576d/7930806/009754c79895/gr5_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/576d/7930806/3827973c6408/gr6_lrg.jpg

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