Chung Anna, Rahimi Asal, Wandrey Narine, Arbab Mona
Medicine, University of Texas Southwestern Medical Center, Dallas, USA.
Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, USA.
Cureus. 2025 May 27;17(5):e84907. doi: 10.7759/cureus.84907. eCollection 2025 May.
Radiation recall phenomenon (RRP) is a rare inflammatory reaction in previously irradiated tissue triggered by agents such as chemotherapy or vaccines. A 67-year-old female patient who had undergone radiation to the right thigh for liposarcoma developed a blister at the same site during whole breast radiation for invasive lobular carcinoma. This occurred three days after receiving COVID-19, respiratory syncytial virus (RSV), and influenza vaccines. The reaction progressed to an ulcer over two months, while her active breast radiation site remained unaffected. This case highlights vaccination as a potential RRP trigger and the selective involvement of prior radiation fields. Awareness of RRP in vaccinated patients with a history of radiation is essential, warranting further research into its mechanisms.
放射回忆现象（RRP）是一种罕见的炎症反应，发生在先前接受过放射治疗的组织中，由化疗或疫苗等因素引发。一名67岁女性患者曾因脂肪肉瘤接受右大腿放疗，在因浸润性小叶癌进行全乳放疗期间，同一部位出现水疱。这发生在接种新冠病毒、呼吸道合胞病毒（RSV）和流感疫苗三天后。反应在两个月内进展为溃疡，而她正在进行放疗的乳腺部位未受影响。该病例突出了疫苗接种作为RRP潜在触发因素以及先前放疗区域的选择性受累情况。认识到有放疗史的接种疫苗患者中的RRP至关重要，这需要对其机制进行进一步研究。
