Duarte-Silva Eduardo, Clarke Gerard, Dinan Timothy G, Peixoto Christina Alves
Laboratory of Ultrastructure, Aggeu Magalhães Institute (IAM), Oswaldo Cruz Foundation (FIOCRUZ-PE), Recife, Brazil.
Postgraduate Program in Biosciences and Biotechnology for Health (PPGBBS), Aggeu Magalhães Institute (IAM), Recife, Brazil.
Neuroimmunomodulation. 2021;28(2):47-51. doi: 10.1159/000514094. Epub 2021 Mar 5.
Major depressive disorder (MDD) is a chronic affective disorder that has a strong neuroinflammatory component underpinning its etiology. Recent studies indicate that MDD is also associated with changes in the gut microbiota and that the latter is mainly modulated by diet. Microbiota-based personalized nutrition aims to provide an individual-specific diet that will yield the maximum benefit from a given diet since the gut microbiota is accounted for the variations that individuals present in response to a given food. In this review, we present and discuss 5 possible outcomes of using microbiota-based personalized nutrition. Harnessing this approach is essential to design more accurate therapies to prevent and treat MDD or to even help in drug metabolism, especially in the case of antidepressants.
重度抑郁症（MDD）是一种慢性情感障碍，其病因有很强的神经炎症成分。最近的研究表明，MDD还与肠道微生物群的变化有关，而肠道微生物群主要受饮食调节。基于微生物群的个性化营养旨在提供一种因人而异的饮食，鉴于肠道微生物群是个体对特定食物反应差异的原因，这种饮食能从给定饮食中获得最大益处。在这篇综述中，我们展示并讨论了使用基于微生物群的个性化营养的5种可能结果。采用这种方法对于设计更精确的疗法以预防和治疗MDD甚至有助于药物代谢至关重要，尤其是在抗抑郁药的情况下。
