Centre for Clinical Research, North Denmark Regional Hospital, Hjoerring, Denmark.
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
Brain Behav. 2021 Jul;11(7):e02177. doi: 10.1002/brb3.2177. Epub 2021 May 28.
The etiology of major depressive disorder (MDD) is multi-factorial and has been associated with a perturbed gut microbiota. Thus, it is therefore of great importance to determine any variations in gut microbiota in patients with MDD.
A systematic literature search was conducted including original research articles based on gut microbiota studies performed in patients with MDD. Demographic and clinical characteristics, applied methodology and observed gut microbiota composition were compared between included studies.
Seventeen studies were included with a total of 738 patients with MDD and 782 healthy controls using different DNA purification methods, sequencing platforms and data analysis models. Four studies found a reduced α-diversity in patients with MDD, while gut microbiota compositions clustered separately according to β-diversity between patients and controls in twelve studies. Additionally, there was an increase in relative abundance of Eggerthella, Atopobium, and Bifidobacterium and a decreased relative abundance of Faecalibacterium in patients with MDD compared with healthy controls.
Gut microbiota differs significantly when comparing patients with MDD and healthy controls, though inconsistently across studies. The heterogeneity in gut microbiota compositions between the studies may be explained by variations in study design.
重度抑郁症（MDD）的病因是多因素的，与肠道微生物群失调有关。因此，确定 MDD 患者肠道微生物群的任何变化非常重要。
进行了系统的文献检索，包括基于 MDD 患者肠道微生物群研究的原始研究文章。对纳入研究之间的人口统计学和临床特征、应用方法和观察到的肠道微生物群组成进行了比较。
共纳入 17 项研究，其中包括使用不同 DNA 纯化方法、测序平台和数据分析模型的 738 名 MDD 患者和 782 名健康对照者。四项研究发现 MDD 患者的α多样性降低，而 12 项研究中根据患者和对照者之间的β多样性，肠道微生物群组成聚类分开。此外，与健康对照者相比，MDD 患者的 Eggerthella、Atopobium 和双歧杆菌相对丰度增加，Faecalibacterium 相对丰度降低。
与健康对照者相比，MDD 患者的肠道微生物群存在显著差异，但在研究间不一致。研究之间肠道微生物群组成的异质性可能解释了研究设计的变化。
