Department of Internal Medicine, Faculty of Medicine, Universidade Federal de Minas Gerais, Avenida Alfredo Balena, 190 2nd Floor, Room 255, Belo Horizonte, MG, 30130-100, Brazil.
Fundacao de Hematologia e Hemoterapia de Pernambuco (HEMOPE), Recife, Brazil.
Int J Hematol. 2021 Jun;113(6):884-892. doi: 10.1007/s12185-021-03104-y. Epub 2021 Mar 7.
Since the introduction of episodic and prophylactic treatments with safer factor concentrates, the life expectancy of people with haemophilia (PwH) has improved considerably. Ageing-related diseases such as cardiovascular disease (CVD) have also become more prevalent in PwH. This cross-sectional study aimed to evaluate CVD risk factors and estimate 10-year risk for CVD events among PwH. Male patients ≥ 30 years were interviewed and examined. Blood tests were performed at the local laboratory. Eighty-two patients were included, of whom 83% had haemophilia A and half had severe disease. Median age at study entry was 43.0 years (interquartile range [IQR], 36.0-51.3). Prevalence of obesity, systemic arterial hypertension (SAH) and diabetes mellitus were 16%, 60% and 16%, respectively. Hypertriglyceridaemia, hypercholesterolaemia and low HDL blood levels were present in 18%, 41% and 30% of patients, respectively. Metabolic syndrome was found in 37%. The Framingham Risk Score showed that 39% of PwH had a high risk of developing cardiovascular events in the following 10 years. We conclude that, in this cohort, PwH have a higher prevalence of SAH when compared with Brazilian men without haemophilia and about two-fifths have a high risk of developing a CVD event in the following 10 years.
自采用更安全的因子浓缩物进行间歇性和预防性治疗以来，血友病患者（PwH）的预期寿命有了显著提高。与年龄相关的疾病，如心血管疾病（CVD），在 PwH 中也变得更为普遍。本横断面研究旨在评估 CVD 风险因素，并估计 PwH 发生 CVD 事件的 10 年风险。对年龄≥30 岁的男性患者进行访谈和检查。在当地实验室进行血液检查。共纳入 82 名患者，其中 83%为血友病 A，一半为重度疾病。研究入组时的中位年龄为 43.0 岁（四分位距 [IQR]，36.0-51.3）。肥胖、系统性动脉高血压（SAH）和糖尿病的患病率分别为 16%、60%和 16%。分别有 18%、41%和 30%的患者存在高甘油三酯血症、高胆固醇血症和低 HDL 血水平。37%的患者存在代谢综合征。Framingham 风险评分显示，39%的 PwH 在未来 10 年内发生心血管事件的风险较高。我们的结论是，在本队列中，与没有血友病的巴西男性相比，PwH 的 SAH 患病率更高，大约五分之二的患者在未来 10 年内有发生 CVD 事件的高风险。
