Departments of Neurology, Keio University School of Medicine, Japan.
Departments of Endocrinology, Metabolism, and Nephrology, Keio University School of Medicine, Japan.
Intern Med. 2021 Aug 15;60(16):2693-2696. doi: 10.2169/internalmedicine.6975-20. Epub 2021 Mar 8.
Although headache attributed to hypothyroidism is coded within The International Classification of Headache Disorders, 3rd edition, an association between headache and thyrotoxicosis (hyperthyroidism) is mentioned only in the appendix. Reports on relevant cases are too scarce to establish a causal relationship. A young man with a history of migraine with aura arrived at our headache clinic with a 10-day history of headache and weight loss. Brain MRI revealed normal findings. Blood tests revealed thyrotoxicosis. A test for thyroid-related antibodies was negative. Thus, the patient was diagnosed with painless thyroiditis. The patient's headache resolved as his thyroid hormone levels decreased. To the best of our knowledge, this is the first reported case of headache exaggerated by painless thyrotoxicosis.
尽管归因于甲状腺功能减退症的头痛被编码在《国际头痛疾病分类》第 3 版中，但头痛与甲状腺毒症（甲状腺功能亢进症）之间的关联仅在附录中提及。相关病例报告太少，无法建立因果关系。一位有先兆偏头痛病史的年轻男性因头痛和体重减轻 10 天来到我们的头痛诊所。脑部 MRI 显示正常。血液检查显示甲状腺功能亢进。甲状腺相关抗体检测为阴性。因此，该患者被诊断为无痛性甲状腺炎。随着甲状腺激素水平的降低，患者的头痛得到缓解。据我们所知，这是首例由无痛性甲状腺毒症引起的头痛加重的报道病例。
