Parodi S, Taningher M, Santi L
Department of Clinical and Experimental Oncology, University of Genoa/Istituto Nazionale per la Ricerca sul Cancro, Italy.
Mutat Res. 1988 May-Aug;205(1-4):283-94. doi: 10.1016/0165-1218(88)90023-7.
In this paper we discuss the possibility of utilizing not only the qualitative component of the information obtained from long-term and short-term tests (as is customary), but also the quantitative component of the results. We suggest that there is probably a precise mathematical relationship between the qualitative and quantitative approaches. We show that utilizing the quantitative approach, it is possible to give confidence limits to a given prediction, a possibility potentially very useful for risk evaluation. We show that starting from a reasonable working hypothesis, it is possible to include even negative data in a unified quantitative approach. Incorporating the quantitative component of the information could offer appreciable gains in predictivity, especially when utilizing batteries of tests.
在本文中,我们讨论了不仅利用从长期和短期测试中获得的信息的定性成分(按照惯例),还利用结果的定量成分的可能性。我们认为定性和定量方法之间可能存在精确的数学关系。我们表明,利用定量方法,可以为给定的预测给出置信区间,这一可能性对于风险评估可能非常有用。我们表明,从合理的工作假设出发,甚至可以将负面数据纳入统一的定量方法中。纳入信息的定量成分可以在预测性方面带来显著提升,尤其是在使用一系列测试时。