Parodi S, Malacarne D, Taningher M
Istituto di Oncologia Clinica e Sperimentale e CIRC, Università di Genova, Italy.
Environ Health Perspect. 1991 Dec;96:61-6. doi: 10.1289/ehp.919661.
In this paper we give some examples of using databases of genotoxicity and carcinogenicity for quantitative and qualitative correlation studies between short-term tests and carcinogenicity. The quality of the databases is obviously important, but one of the major deficiencies of present databases is that they are too small. Using relatively small, different databases, different results can be obtained. With small databases it is difficult to disaggregate data for homogeneous chemical classes or other types of subsets. Using the databases of Gold (carcinogenicity) and Würgler (genotoxicity), we have investigated the carcinogenic potency of genotoxic and nongenotoxic carcinogens for different chemical classes.
在本文中，我们给出了一些利用遗传毒性和致癌性数据库进行短期试验与致癌性之间定量和定性相关性研究的例子。数据库的质量显然很重要，但目前数据库的主要缺陷之一是它们规模太小。使用相对较小的、不同的数据库，可能会得到不同的结果。对于小型数据库而言，难以对同类化学物质或其他类型的子集进行数据分类。利用戈尔德（致癌性）和维尔格勒（遗传毒性）的数据库，我们研究了不同化学类别中遗传毒性致癌物和非遗传毒性致癌物的致癌效力。
