Saylan Sedat, Akbulut Ulas Emre
Sedat Saylan, MD. Faculty of Medicine, Department of Anesthesiology, Karadeniz Technical University, Trabzon, Turkey.
Ulas Emre Akbulut, Department of Pediatric Gastroenterology Hepatology & Nutrition, University of Health Sciences, Antalya Education and Research Hospital, Antalya, Turkey.
Pak J Med Sci. 2021 Mar-Apr;37(2):483-488. doi: 10.12669/pjms.37.2.2787.
To compare the efficacy and safety of midazolam-ketamine combination versus fentanyl-propofol combination in pediatric diagnostic colonoscopy.
This is a retrospective study of 68 children undergoing diagnostic gastroenterology with midazolam-ketamine combination (Group-K) or with fentanyl-propofol combination (Group-P) in the pediatric gastroentology department at a Turkish tertiary hospital between January 2015 and June 2017. An intravenous midazolam was administered one minute before ketamine administration in Group K. Intravenous fentanyl was given to Group P, followed by intravenous propofol.
There were statistically no significant differences between the groups as for age, gender, weight, duration of colonoscopy and complications observed during procedure. Ramsay sedation score was significantly higher in Group K. Recovery time and the rate of complications during the recovery of Group-K (23 patients, 65.7%) was significantly higher than that of Group P (8 patients, 24.2%) (p= 0.001).
Colonoscopy procedures can be quite comfortable in children when using the midazolam-ketamine combination. However, adverse effects related to ketamine were observed during recovery.
比较咪达唑仑-氯胺酮组合与芬太尼-丙泊酚组合在儿童诊断性结肠镜检查中的疗效和安全性。
这是一项回顾性研究，对2015年1月至2017年6月期间在土耳其一家三级医院儿科胃肠病科接受诊断性胃肠病检查的68名儿童进行研究，这些儿童使用咪达唑仑-氯胺酮组合（K组）或芬太尼-丙泊酚组合（P组）。K组在给予氯胺酮前1分钟静脉注射咪达唑仑。P组先静脉注射芬太尼，然后静脉注射丙泊酚。
两组在年龄、性别、体重、结肠镜检查持续时间和检查过程中观察到的并发症方面，统计学上无显著差异。K组的 Ramsay 镇静评分显著更高。K组（23例患者，65.7%）恢复期间的恢复时间和并发症发生率显著高于P组（8例患者，24.2%）（p = 0.001）。
使用咪达唑仑-氯胺酮组合时，儿童结肠镜检查过程可以相当舒适。然而，在恢复过程中观察到了与氯胺酮相关的不良反应。
