Zuberi Faisal Faiyaz, Zuberi Bader Faiyaz, Ali Faiza Sadaqat, Bader Nimrah
Faisal Faiyaz Zuberi, Ojha Institute of Chest Diseases, Dow University of Health Sciences, Karachi, Pakistan.
Bader Faiyaz Zuberi, Department of Medicine, Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan.
Pak J Med Sci. 2021 Mar-Apr;37(2):536-542. doi: 10.12669/pjms.37.2.3127.
To determine frequency of Muscle Weakness in Non-Hypoxemic COPD out-patients and Comparison with age matched non-COPD Controls.
This cross-sectional study was conducted at OPD of Ojha Institute of Chest Diseases and Medicine, Dow University of Health Sciences, Karachi, Pakistan, during the period 8 September 2019 till 30 May 2020. Patients of both genders aged 25-70 years who were satisfying GOLD criteria for COPD and having SpO ≥ 94% were included. An age matched control group was added as control. Hand Grip Strength (HGS) and Chair to Stand time (CST) were recorded.
Two hundred fifty-six patients were inducted with aged and BMI matched group of non-COPD Control patients in ratio of 1:2 (n = 128). Comparison of HGS between Control and COPD Groups showed significant weakness in COPD group. Significant weakness in lower limbs in COPD Group with longer timings to complete the task. Mean FEV had significant low values in COPD Group. Age correlated negatively with HGS & positively with CST. BMI correlated positively with FEV and CST but negatively with HGS. HGS correlated positively with FEV and no correlation was found with CST. No correlation was found of CST with FEV.
Muscle weakness in COPD patients was shown by simple validated bedside tools. The older COPD patients had less HGS and were slower in doing CST whereas those COPD ones who had higher FEV had more HGS.
确定非低氧血症慢性阻塞性肺疾病（COPD）门诊患者肌肉无力的发生率，并与年龄匹配的非COPD对照组进行比较。
本横断面研究于2019年9月8日至2020年5月30日在巴基斯坦卡拉奇道健康科学大学奥贾胸科疾病与医学研究所的门诊进行。纳入年龄在25 - 70岁、符合COPD全球倡议（GOLD）标准且动脉血氧饱和度（SpO₂）≥94%的男女患者。添加一个年龄匹配的对照组。记录握力（HGS）和从椅子站立时间（CST）。
纳入256例患者，并按1:2的比例纳入年龄和体重指数匹配的非COPD对照组（n = 128）。对照组和COPD组之间的握力比较显示COPD组存在明显无力。COPD组下肢明显无力，完成任务所需时间更长。COPD组的平均第一秒用力呼气容积（FEV₁）值显著较低。年龄与握力呈负相关，与从椅子站立时间呈正相关。体重指数与第一秒用力呼气容积和从椅子站立时间呈正相关，但与握力呈负相关。握力与第一秒用力呼气容积呈正相关，与从椅子站立时间无相关性。从椅子站立时间与第一秒用力呼气容积无相关性。
通过简单有效的床旁工具可显示COPD患者存在肌肉无力。年龄较大 的COPD患者握力较小，从椅子站立的速度较慢，而第一秒用力呼气容积较高的COPD患者握力较大。
