Guarini S, Bertolini A, Lancellotti N, Rompianesi E, Ferrari W
Institute of Pharmacology, University of Modena, Italy.
Pharmacol Res Commun. 1987 Jul;19(7):511-6. doi: 10.1016/0031-6989(87)90111-1.
Cholecystokinin octapeptide (CCK-8) (20 micrograms/kg i.v.) and tetracosactide [ACTH-(1-24)] (160 micrograms/kg i.v.) restore blood pressure and allow rats subjected to otherwise invariably fatal acute hemorrhage to survive. Atropine sulphate (2-8 mg/kg i.p.), which crosses the blood-brain barrier, dose-dependently prevents this effect both in the case of ACTH-(1-24) and in that of CCK-8. On the other hand, atropine methyl bromide (2-8 mg/kg i.p.), which does not cross the blood-brain barrier, prevents the effect in the case of CCK-8, but not in that of ACTH-(1-24). These data suggest that a cholinergic mechanism is involved in the anti-shock effect of both ACTH-(1-24) and CCK-8, though the sites of action appear to be in the CNS, in the case of ACTH-(1-24), and outside the CNS, in that of CCK-8.
八肽胆囊收缩素（CCK - 8）（静脉注射20微克/千克）和二十四肽促肾上腺皮质激素[ACTH - (1 - 24)]（静脉注射160微克/千克）可恢复血压，并使遭受原本必然致命的急性出血的大鼠存活下来。可穿过血脑屏障的硫酸阿托品（腹腔注射2 - 8毫克/千克）在ACTH - (1 - 24)和CCK - 8的情况下均剂量依赖性地阻止这种效应。另一方面，不能穿过血脑屏障的甲基溴化阿托品（腹腔注射2 - 8毫克/千克）可阻止CCK - 8的效应，但不能阻止ACTH - (1 - 24)的效应。这些数据表明，胆碱能机制参与了ACTH - (1 - 24)和CCK - 8的抗休克作用，尽管ACTH - (1 - 24)的作用部位似乎在中枢神经系统，而CCK - 8的作用部位在中枢神经系统之外。
