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蛙皮素和胆囊收缩素可逆转实验性失血性休克。

Caerulein and cholecystokinin reverse experimental hemorrhagic shock.

作者信息

Bertolini A, Guarini S, Ferrari W, Rompianesi E

出版信息

Neuropeptides. 1986 Jul;8(1):25-31. doi: 10.1016/0143-4179(86)90061-2.

DOI:10.1016/0143-4179(86)90061-2
PMID:3762876
Abstract

Intravenously injected cholecystokinin octapeptide (CCK-8) (5-20/micrograms/kg) and caerulein (1.25-10/micrograms/kg) caused a prompt, dose-dependent and sustained improvement in blood pressure, pulse amplitude and survival in rats subjected to otherwise invariably fatal hemorrhagic shock.

摘要

静脉注射八肽胆囊收缩素(CCK - 8)(5 - 20微克/千克)和雨蛙素(1.25 - 10微克/千克)可使遭受通常会致命的失血性休克的大鼠的血压、脉搏幅度和存活率迅速、剂量依赖性且持续地得到改善。

相似文献

1
Caerulein and cholecystokinin reverse experimental hemorrhagic shock.蛙皮素和胆囊收缩素可逆转实验性失血性休克。
Neuropeptides. 1986 Jul;8(1):25-31. doi: 10.1016/0143-4179(86)90061-2.
2
Haematological changes induced by the intravenous injection of CCK-8 in rats subjected to haemorrhagic shock.静脉注射CCK-8对失血性休克大鼠血液学变化的影响。
Neuropeptides. 1988 Feb-Mar;11(2):69-72. doi: 10.1016/0143-4179(88)90012-1.
3
Cholecystokinin peptides and bombesin reverse hemorrhagic shock in rats.胆囊收缩素肽和蛙皮素可逆转大鼠失血性休克。
Resuscitation. 1989 Dec;18(2-3):129-31. doi: 10.1016/0300-9572(89)90005-1.
4
Different cholinergic pathways are involved in the improvement induced by CCK-8 and by ACTH-(1-24) in massive acute hemorrhage, in rats.在大鼠大量急性出血模型中,不同的胆碱能通路参与了CCK - 8和促肾上腺皮质激素(1 - 24)诱导的改善过程。
Pharmacol Res Commun. 1987 Jul;19(7):511-6. doi: 10.1016/0031-6989(87)90111-1.
5
Mechanism of action of the anti-shock effect of CCK-8: influence of CCK antagonists and of sympatholytic drugs.CCK-8抗休克作用的机制:CCK拮抗剂和抗交感神经药物的影响
Pharmacology. 1988;37(5):286-92. doi: 10.1159/000138480.
6
Effect of cholecystokinin octapeptide and ceruletide on release of acetylcholine from cerebral cortex of the rat in vivo.八肽胆囊收缩素及雨蛙肽对大鼠大脑皮质乙酰胆碱释放的影响(体内实验)
Neuropharmacology. 1984 Nov;23(11):1305-9. doi: 10.1016/0028-3908(84)90050-9.
7
Hyperstimulation pancreatitis in mice induced by cholecystokinin octapeptide, caerulein, and novel analogues: effect of molecular structure on potency.由八肽胆囊收缩素、蛙皮素及其新型类似物诱导的小鼠过度刺激型胰腺炎:分子结构对效力的影响
Pancreas. 1991 Jul;6(4):404-6. doi: 10.1097/00006676-199107000-00005.
8
Reduction of food intake by central administration of cholecystokinin octapeptide in the rat is dependent upon inhibition of brain peptidases.通过向大鼠中枢注射八肽胆囊收缩素减少食物摄入量取决于对脑肽酶的抑制作用。
Br J Pharmacol. 1989 Jan;96(1):236-42. doi: 10.1111/j.1476-5381.1989.tb11805.x.
9
L364,718 antagonizes the cholecystokinin-induced suppression of locomotor activity.
Pharmacol Biochem Behav. 1989 Jul;33(3):637-40. doi: 10.1016/0091-3057(89)90401-2.
10
Neuroleptic-like properties of cholecystokinin analogs: distinctive mechanisms underlying similar behavioral profiles depending on the route of administration.胆囊收缩素类似物的抗精神病样特性:取决于给药途径的相似行为特征背后的独特机制。
Peptides. 1988 Jul-Aug;9(4):739-43. doi: 10.1016/0196-9781(88)90115-5.

引用本文的文献

1
Heme oxygenase-1 in cholecystokinin-octapeptipe attenuated injury of pulmonary artery smooth muscle cells induced by lipopolysaccharide and its signal transduction mechanism.胆囊收缩素八肽中血红素加氧酶-1减轻脂多糖诱导的肺动脉平滑肌细胞损伤及其信号转导机制
World J Gastroenterol. 2004 Jun 15;10(12):1789-94. doi: 10.3748/wjg.v10.i12.1789.
2
Effect of cholecystokinin on cytokines during endotoxic shock in rats.胆囊收缩素对大鼠内毒素休克期间细胞因子的影响。
World J Gastroenterol. 2001 Oct;7(5):667-71. doi: 10.3748/wjg.v7.i5.667.
3
Contrasting effects of circulating nitric oxide and nitrergic transmission on exocrine pancreatic secretion in rats.
循环一氧化氮和氮能传递对大鼠胰腺外分泌的不同影响。
Gut. 1998 Nov;43(5):684-91. doi: 10.1136/gut.43.5.684.