便携式呼吸气体分析仪的研制及其在间接静息能量消耗（REE）测量中的应用。
Development of a Portable Respiratory Gas Analyzer for Measuring Indirect Resting Energy Expenditure (REE).
机构信息
Department of Biomedical Engineering, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Department of Physiology, Ulsan College of Medicine, Seoul, Republic of Korea.
出版信息
J Healthc Eng. 2021 Feb 17;2021:8870749. doi: 10.1155/2021/8870749. eCollection 2021.
OBJECTIVE
A rapidly growing home healthcare market has resulted in the development of many portable or wearable products. Most of these products measure, estimate, or calculate physiologic signals or parameters, such as step counts, blood pressure, or electrocardiogram. One of the most important applications in home healthcare is monitoring one's metabolic state since the change of metabolic state could reveal minor or major changes in one's health condition. A simple and noninvasive way to measure metabolism is through breath monitoring. With breath monitoring by breath gas analysis, two important indicators like the respiratory quotient (RQ) and resting energy exposure (REE) can be calculated. Therefore, we developed a portable respiratory gas analyzer for breath monitoring to monitor metabolic state, and the performance of the developed device was tested in a clinical trial. . The subjects consisted of 40 healthy men and women. Subjects begin to measure exhalation gas using Vmax 29 for 15 minutes. After that, subjects begin to measure exhalation gas via the developed respiratory gas analyzer. Finally, the recorded data on the volume of oxygen (VO), volume of carbon dioxide (VCO), RQ, and REE were used to validate correlations between Vmax 29 and the developed respiratory gas analyzer.
RESULTS
The results showed that the root-mean-square errors (RMSE) values of VCO, VO, RQ, and REE are 0.0315, 0.0417, 0.504, and 0.127. Bland-Altman plots showed that most of the VCO, VO, RQ, and REE values are within 95% of the significance level.
CONCLUSIONS
We have successfully developed and tested a portable respiratory gas analyzer for home healthcare. However, there are limitations of the clinical trial; the number of subjects is small in size, and the age and race of subjects are confined. The developed portable respiratory gas analyzer is a cost-efficient method for measuring metabolic state and a new application of home healthcare.
目的
快速发展的家庭医疗保健市场催生了许多便携式或可穿戴产品。这些产品大多测量、估计或计算生理信号或参数，如步数、血压或心电图。家庭医疗保健中最重要的应用之一是监测人体的代谢状态，因为代谢状态的变化可能揭示人体健康状况的细微或重大变化。一种简单且非侵入性的测量代谢的方法是通过呼吸监测。通过呼吸气体分析进行呼吸监测，可以计算出两个重要指标，即呼吸商（RQ）和静息能量消耗（REE）。因此，我们开发了一种用于呼吸监测的便携式呼吸气体分析仪来监测代谢状态，并在临床试验中测试了该开发设备的性能。研究对象由 40 名健康的男性和女性组成。研究对象首先使用 Vmax 29 测量 15 分钟的呼气气体。之后，研究对象开始使用开发的呼吸气体分析仪测量呼气气体。最后，记录的氧气（VO）体积、二氧化碳（VCO）体积、RQ 和 REE 数据用于验证 Vmax 29 和开发的呼吸气体分析仪之间的相关性。
结果
结果表明，VCO、VO、RQ 和 REE 的均方根误差（RMSE）值分别为 0.0315、0.0417、0.504 和 0.127。Bland-Altman 图显示，大多数 VCO、VO、RQ 和 REE 值都在 95%的置信水平内。
结论
我们已经成功开发并测试了一种用于家庭医疗保健的便携式呼吸气体分析仪。然而，临床试验存在局限性，研究对象数量较少，且研究对象的年龄和种族受到限制。开发的便携式呼吸气体分析仪是一种经济高效的测量代谢状态的方法，也是家庭医疗保健的新应用。
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