Sani A, Abdullahi I L, Ibrahim S
Department of Instrument Science and Engineering, School of Electronic, Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.
Department of Biological Sciences, Bayero University Kano, P.M.B. 3011, Kano, Nigeria.
Toxicol Rep. 2021 Feb 25;8:422-428. doi: 10.1016/j.toxrep.2021.02.016. eCollection 2021.
Welding fumes has been known to cause release of reactive oxygen species which stands to be cytotoxic. The study aims to assess the histopathological changes of some organs associated with exposure to welding fumes in experimental animals. The metal fumes were obtained from sites of welding. A total of 130 male albino rats were engaged and divided into a 13 groups. Out of which 12 were given respective doses calculated to be equivalent to worker's real life exposure times and 1 as control. The doses were intratracheally administered weekly following anesthetization for a period of 12 weeks. The laboratory rats were then sacrificed and target organs were examined. Histopathological examination reveals normal feature for brain tissues in all treated animals. However, there was lymphocyte hyperplasia and necrosis in heart, kidney, liver and lungs tissues which at lower doses were slight and became moderate at higher doses. In addition, there were'nt pathological changes in tissues of the control animals. Thus, exposure to metal welding fumes has caused damages that have translated into lesions and several pathologies in kidney, lungs, liver and heart tissues of the test animals. Regulation and control should be imposed on exposure to welding fumes by metal workers.
众所周知，焊接烟雾会导致活性氧的释放，而活性氧具有细胞毒性。本研究旨在评估实验动物接触焊接烟雾后某些器官的组织病理学变化。金属烟雾取自焊接现场。总共使用了130只雄性白化大鼠，并将其分为13组。其中12组给予按工人实际接触时间计算的相应剂量，1组作为对照组。在麻醉后每周经气管内给药，持续12周。然后处死实验大鼠并检查靶器官。组织病理学检查显示，所有处理动物的脑组织均为正常特征。然而，心脏、肾脏、肝脏和肺组织出现淋巴细胞增生和坏死，低剂量时较轻，高剂量时变为中度。此外，对照动物的组织未出现病理变化。因此，接触金属焊接烟雾已造成损害，导致受试动物的肾脏、肺、肝脏和心脏组织出现病变和多种病理状况。金属工人接触焊接烟雾的情况应加以规范和控制。
