18F-DCFPyL前列腺特异性膜抗原正电子发射断层扫描/计算机断层扫描用于前列腺癌评估的荟萃分析

Evaluation of 18F-DCFPyL PSMA PET/CT for Prostate Cancer: A Meta-Analysis.

作者信息

Pan Ke-Hao, Wang Jin-Feng, Wang Chun-Ying, Nikzad Abdul Aziz, Kong Fang Q, Jian Li, Zhang Yin-Qiu, Lu Xiao-Ming, Xu Bin, Wang Ya-Li, Chen Ming

机构信息

Department of Urology, Affiliated Zhongda Hospital of Southeast University, Southeast University, Nanjing, China.

Lishui District People's Hospital, Nanjing, China.

出版信息

Front Oncol. 2021 Feb 17;10:597422. doi: 10.3389/fonc.2020.597422. eCollection 2020.

BACKGROUND

To systematically review the clinical value of 18F-DCFPyL prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT) in the diagnosis of prostate cancer (PCa).

METHODS

Literature concerning 18F-DCFPyL PSMA PET/CT in the diagnosis of prostate cancer published from 2015 to 2020 was electronically searched in the databases including PubMed and Embase. Statistical analysis was carried out with STATA 15 software, and the quality of included studies was tested with quality assessment of diagnostic accuracy studies (QUADAS) items. The heterogeneity of the included data was tested.

RESULTS

In total, nine pieces of literature involving 426 patients met the inclusion criteria. The heterogeneity of the study group was not obvious. The SEN, SPE, LR+, LR-, DOR as well as AUC of 18F-DCFPyL PSMA PET/CT diagnosis of prostate cancer were 0.91, 0.90, 8.9, 0.10, 93, and 0.93. The pooled DR of 18F-DCFPyL labeled PSMA PET/CT in PCa was 92%. The pooled DR was 89% for PSA≥0.5 ng/ml and 49% for PSA < 0.5ng/ml.

CONCLUSION

18F-DCFPyL PSMA PET/CT had good sensitivity and specificity for the diagnosis of prostate cancer. The DR of 18F-DCFPyL PSMA PET/CT was correlated with PSA value. Further large-sample, high-quality studies were needed.

背景

系统评价¹⁸F-DCFPyL前列腺特异性膜抗原正电子发射断层扫描/计算机断层扫描（PSMA PET/CT）在前列腺癌（PCa）诊断中的临床价值。

方法

在包括PubMed和Embase在内的数据库中，对2015年至2020年发表的有关¹⁸F-DCFPyL PSMA PET/CT诊断前列腺癌的文献进行电子检索。使用STATA 15软件进行统计分析，并用诊断准确性研究的质量评估（QUADAS）项目对纳入研究的质量进行检验。检验纳入数据的异质性。

结果

总共9篇涉及426例患者的文献符合纳入标准。研究组的异质性不明显。¹⁸F-DCFPyL PSMA PET/CT诊断前列腺癌的敏感性（SEN）、特异性（SPE）、阳性似然比（LR+）、阴性似然比（LR-）、诊断比值比（DOR）以及曲线下面积（AUC）分别为0.91、0.90、8.9、0.10、93和0.93。¹⁸F-DCFPyL标记的PSMA PET/CT在PCa中的合并诊断率（DR）为92%。对于前列腺特异性抗原（PSA）≥0.5 ng/ml，合并DR为89%；对于PSA < 0.5 ng/ml，合并DR为49%。