Perico Norberto, Fagiuoli Stefano, Di Marco Fabiano, Laghi Andrea, Cosentini Roberto, Rizzi Marco, Gianatti Andrea, Rambaldi Alessandro, Ruggenenti Piero, La Vecchia Carlo, Bertolini Guido, Paglia Stefano, Lorini Ferdinando Luca, Remuzzi Giuseppe
Istituto di Ricerche Farmacologiche Mario Negri, IRCCS, Bergamo, Italy.
Gastroenterology Hepatology and Transplantation, Department of Medicine, ASST-Papa Giovanni XXIII, Bergamo, Italy.
Front Med (Lausanne). 2021 Feb 19;8:609440. doi: 10.3389/fmed.2021.609440. eCollection 2021.
The novel coronavirus, SARS-CoV-2, continues to spread rapidly. Here we discuss the dramatic situation created by COVID-19 in Italy, particularly in the province of Bergamo (the most severely affected in the first wave), as an example of how, in the face of an unprecedented tragedy, acting (albeit belatedly)-including imposing a very strict lockdown-can largely resolve the situation within approximately 2 months. The measures taken here ensured that Bergamo hospital, which was confronted with rapidly rising numbers of severely ill COVID-19 patients requiring hospitalization, was able to meet the initial challenges of the pandemic. We also report that local organization and, more important, the large natural immunity against SARS-CoV-2 of the Bergamo population developed during the first wave of the epidemic, can explain the limited number of new COVID-19 cases during the more recent second wave compared to the numbers in other areas of Lombardy. Furthermore, we highlight the importance of coordinating the easing of containment measures to avoid what is currently observed in other countries, especially in the United States, Latin American and India, where this approach has not been adopted, and a dramatic resurgence of COVID-19 cases and an increase in the number of hospitalisations and deaths have been reported.
新型冠状病毒SARS-CoV-2仍在迅速传播。在此，我们以意大利，尤其是贝加莫省（第一波疫情中受影响最严重的地区）因新冠疫情所造成的严峻形势为例，说明面对一场前所未有的悲剧时，采取行动（尽管有所延迟）——包括实施非常严格的封锁措施——如何能够在大约两个月内很大程度上缓解局势。这里采取的措施确保了贝加莫医院能够应对新冠疫情中迅速增加的需要住院治疗的重症患者带来的最初挑战。我们还报告称，当地的组织，更重要的是，在第一波疫情期间贝加莫人群对SARS-CoV-2产生的强大自然免疫力，可以解释与伦巴第其他地区相比，在最近的第二波疫情中该地区新冠新增病例数量有限的原因。此外，我们强调协调放宽遏制措施的重要性，以避免目前在其他国家，特别是美国、拉丁美洲和印度所出现的情况，在这些国家没有采取这种做法，已报告出现了新冠病例的急剧反弹以及住院和死亡人数的增加。
