Department of Ophthalmology, Second Affiliated Hospital of Soochow University, China.
Department of Ophthalmology, Huashan Hospital North, Fudan University, China.
J Diabetes Res. 2021 Feb 23;2021:6644691. doi: 10.1155/2021/6644691. eCollection 2021.
To study retinal function defects in type 2 diabetic patients without clinically apparent retinopathy using a multifocal electroretinogram (mf-ERG).
Seventy-six eyes of thirty-eight type 2 diabetes mellitus(DM) patients without clinically apparent retinopathy and sixty-four normal eyes of thirty-two healthy control (HC) participants were examined using mf-ERG.
Patients with type 2 DM without apparent diabetic retinopathy demonstrated an obvious implicit time delay of P1 in ring 1, ring 3, and ring 5 compared with healthy controls ( = 5.184, ≤ 0.001; = 8.077, ≤ 0.001; = 2.000, = 0.047, respectively). The implicit time (IT) in ring 4 of N1wave was significantly delayed in the DM group ( = 2.327, = 0.021). Compared with the HC group, the implicit time of the P1 and N1 waves in the temporal retina zone was significantly prolonged ( = 3.66, ≤ 0.001; = 2.187, = 0.03, respectively). And the amplitude of P1 in the temporal retina decreased in the DM group, which had a significantly statistical difference with the healthy controls ( = -6.963, ≤ 0.001). However, there were no differences in either the amplitude of the response or the implicit time of the nasal retina zone between DM and HC. The AUC of multiparameters of mf-ERG was higher in the diagnosis of DR patients.
Patients with type 2 DM without clinically apparent retinopathy had a delayed implicit time of P1 wave in temporal regions of the postpole of the retina compared with HC subjects. It demonstrates that mf-ERG can detect the abnormal retinal change in the early stage of type2 DM patients without apparent diabetic retinopathy. Multiparameters of mf-ERG can improve the diagnostic efficacy of DR, and it may be a potential clinical biomarker for early diagnosis of DR.
使用多焦视网膜电图（mf-ERG）研究无临床明显视网膜病变的 2 型糖尿病患者的视网膜功能缺陷。
对 38 例 2 型糖尿病（DM）患者的 76 只眼（无临床明显糖尿病视网膜病变）和 32 例健康对照（HC）参与者的 64 只正常眼进行 mf-ERG 检查。
无明显糖尿病性视网膜病变的 2 型糖尿病患者的 P1 波在环 1、环 3 和环 5 的潜伏期明显延迟（ = 5.184， ≤ 0.001； = 8.077， ≤ 0.001； = 2.000， = 0.047，分别）。DM 组 N1 波中 4 环的潜伏期明显延迟（ = 2.327， = 0.021）。与 HC 组相比，DM 组颞区 P1 和 N1 波的潜伏期明显延长（ = 3.66， ≤ 0.001； = 2.187， = 0.03，分别）。DM 组颞区 P1 波的振幅降低，与健康对照组有显著统计学差异（ = -6.963， ≤ 0.001）。然而，DM 组和 HC 组之间鼻侧视网膜区的反应幅度或潜伏期均无差异。mf-ERG 多参数的 AUC 在 DR 患者的诊断中更高。
与 HC 受试者相比，无临床明显视网膜病变的 2 型糖尿病患者的后极视网膜颞区 P1 波潜伏期延迟。这表明 mf-ERG 可以检测无明显糖尿病性视网膜病变的 2 型糖尿病患者早期视网膜的异常变化。mf-ERG 的多参数可以提高 DR 的诊断效果，可能是 DR 早期诊断的潜在临床生物标志物。
