Barabutis Nektarios
School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, LA 71201, USA.
Aging Brain. 2021;1. doi: 10.1016/j.nbas.2021.100009. Epub 2021 Feb 22.
Blood brain barrier hyperpermeability has been associated with age-related affective disorders, including depression, mania, anxiety, Alzheimer's and Parkinson's disease. Our recent efforts suggest that a promising therapeutic approach may arise due to the activation of the unfolded protein response (UPR) element in the affected tissues. Growth hormone releasing hormone antagonists and heat shock protein 90 inhibitors have been shown to induce UPR. This mechanism (UPR) has been associated with tissue repairing processes.
血脑屏障通透性增加与年龄相关的情感障碍有关，包括抑郁症、躁狂症、焦虑症、阿尔茨海默病和帕金森病。我们最近的研究表明，由于受影响组织中未折叠蛋白反应（UPR）元件的激活，可能会出现一种有前景的治疗方法。生长激素释放激素拮抗剂和热休克蛋白90抑制剂已被证明可诱导UPR。这种机制（UPR）与组织修复过程有关。
