Mukherjee Sitabja, Mishra Awdhesh Kumar, Peer G D Ghouse, Bagabir Sali Abubaker, Haque Shafiul, Pandey Ramendra Pati, Raj V Samuel, Jain Neeraj, Pandey Atul, Kar Santosh Kumar
School of Biotechnology, KIIT University, Bhubaneswar, India.
Department of Biotechnology, Yeungnam University, Gyeongsan, South Korea.
Front Aging Neurosci. 2021 Nov 19;13:767493. doi: 10.3389/fnagi.2021.767493. eCollection 2021.
Abnormal accumulation of misfolded proteins in the endoplasmic reticulum and their aggregation causes inflammation and endoplasmic reticulum stress. This promotes accumulation of toxic proteins in the body tissues especially brain leading to manifestation of neurodegenerative diseases. The studies suggest that deregulation of proteostasis, particularly aberrant unfolded protein response (UPR) signaling, may be a common morbific process in the development of neurodegeneration. Curcumin, the mixture of low molecular weight polyphenolic compounds from turmeric, has shown promising response to prevents many diseases including current global severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and neurodegenerative disorders. The UPR which correlates positively with neurodegenerative disorders were found affected by curcumin. In this review, we examine the evidence from many model systems illustrating how curcumin interacts with UPR and slows down the development of various neurodegenerative disorders (ND), e.g., Alzheimer's and Parkinson's diseases. The recent global increase in ND patients indicates that researchers and practitioners will need to develop a new pharmacological drug or treatment to manage and cure these neurodegenerative diseases.
内质网中错误折叠蛋白的异常积累及其聚集会引发炎症和内质网应激。这会促使有毒蛋白质在身体组织尤其是大脑中积累，从而导致神经退行性疾病的表现。研究表明，蛋白质稳态失调，特别是异常的未折叠蛋白反应（UPR）信号传导，可能是神经退行性变发展过程中的一个常见致病过程。姜黄素是姜黄中低分子量多酚化合物的混合物，已显示出对预防包括当前全球严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染和神经退行性疾病在内的多种疾病有良好效果。发现与神经退行性疾病呈正相关的UPR受到姜黄素的影响。在这篇综述中，我们研究了来自许多模型系统的证据，这些证据说明了姜黄素如何与UPR相互作用并减缓各种神经退行性疾病（ND）如阿尔茨海默病和帕金森病的发展。最近全球ND患者数量的增加表明，研究人员和从业者将需要开发一种新的药物或治疗方法来管理和治愈这些神经退行性疾病。
