HTLV 筛查试验的特异性及其对保健计划成本的影响：巴西产前筛查的观点。
Specificity of HTLV screening tests and its impact on health care program costs: The perspective of antenatal screening in Brazil.
机构信息
Imperial College London, Section of Virology, Department of Infectious Disease, London, United Kingdom.
Instituto Adolfo Lutz, Centro de Imunologia, Laboratório de Pesquisa em HTLV, São Paulo, SP, Brasil.
出版信息
Rev Soc Bras Med Trop. 2021 Mar 8;54. doi: 10.1590/0037-8682-0853-2020. eCollection 2021.
Abstract
INTRODUCTION
Brazil ranks first in the number of HTLV-1/-2-infected individuals worldwide. The high morbidity and mortality of HTLV-1-associated diseases, especially following infection in infancy, requires strong action to reduce vertical transmission.
METHODS
To facilitate the appraisal of the implementation of the HTLV antenatal screening program by the Brazilian Ministry of Health, we determined the costs in distinct scenarios according to HTLV seroprevalence, specificity of the screening test, and type of confirmatory test.
RESULTS
HTLV antenatal screening would cost R$ 55,777,012-R$ 77,082,123/year. Screening assays with high specificity reduce the need and cost of confirmatory assays by up to 25%.
CONCLUSIONS
Careful selection of the screening assay is required to optimize the program.
摘要
引言
巴西的 HTLV-1/-2 感染者数量居世界首位。HTLV-1 相关疾病的高发病率和死亡率，尤其是在婴儿期感染后，需要采取强有力的措施来降低垂直传播。
方法
为了便于巴西卫生部评估 HTLV 产前筛查计划的实施情况，我们根据 HTLV 血清流行率、筛查试验的特异性和确认试验的类型，确定了不同情况下的成本。
结果
HTLV 产前筛查每年将花费 55777012 雷亚尔至 77082123 雷亚尔。特异性高的筛查试验可将确认试验的需求和成本降低多达 25%。
结论
需要仔细选择筛查试验，以优化该计划。
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