巴西人体 T 淋巴细胞病毒的实验室诊断：检测方法、流程图、挑战和展望。
Laboratory diagnosis of human T-lymphotropic virus in Brazil: assays, flowcharts, challenges, and perspectives.
机构信息
Instituto Adolfo Lutz, Centro de Imunologia, Laboratório de Pesquisa em HTLV, São Paulo, SP, Brasil.
Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Laboratório de Virologia Básica e Aplicada, Belo Horizonte, MG, Brasil.
出版信息
Rev Soc Bras Med Trop. 2021 Jun 2;54:e01752021. doi: 10.1590/0037-8682-0175-2021. eCollection 2021.
INTRODUCTION
We present a data analysis and review of recent studies regarding the laboratory diagnosis of human T-lymphotropic virus 1 and 2 (HTLV-1/2) infections in Brazil.
METHODS
Target populations, available diagnostic serological assays (screening and complementary tests), molecular assays (in-house), causes of false-positive and false-negative results, and flowcharts were analyzed.
RESULTS
A table presents the target populations, two diagnostic flowcharts (depending on laboratory infrastructure and study population), and recent research that may improve how HTLV-1/2 is diagnosed in Brazil.
CONCLUSIONS
Our results support the implementation of public policies to reduce HTLV-1/2 transmission and its associated diseases.
简介
我们对巴西近期有关人类 T 淋巴细胞病毒 1 和 2（HTLV-1/2）感染的实验室诊断的研究进行了数据分析和综述。
方法
分析了目标人群、现有的诊断血清学检测方法（筛查和补充检测）、分子检测方法（内部）、假阳性和假阴性结果的原因以及流程图。
结果
呈现了目标人群、两个诊断流程图（根据实验室基础设施和研究人群而定）以及最近可能改进巴西 HTLV-1/2 诊断方法的研究。
结论
我们的结果支持实施公共政策以减少 HTLV-1/2 的传播及其相关疾病。
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