Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Nutrition, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Nutr Cancer. 2022;74(2):405-422. doi: 10.1080/01635581.2021.1897631. Epub 2021 Mar 7.
This systematic review was performed with a focus on the effects of quercetin (QT) on the human breast cancer cell lines MCF-7 and MDA-MB-231. PubMed, Scopus, Science Direct, and Google Scholar databases were searched up to May 2020 using relevant keywords. All articles written in English evaluating the effects of QT on the human breast cancer cell lines MCF-7 and/or MDA-MB-231 were eligible for the review. Totally, 31 articles were included in this review. Out of them, 23 studies investigated the effects of QT on MCF-7 cells and indicated that QT induces apoptosis in the cells. Of 15 studies that examined the effects of QT on MDA-MB-231 cells, 14 reports showed successful apoptosis. It is concluded that QT might be beneficial in the eliminating of breast cancer cells. However, further clinical trials are warranted to further verify these outcomes.
本系统评价重点关注槲皮素（QT）对人乳腺癌细胞系 MCF-7 和 MDA-MB-231 的影响。使用相关关键字，截至 2020 年 5 月，检索了 PubMed、Scopus、Science Direct 和 Google Scholar 数据库。所有评估 QT 对人乳腺癌细胞系 MCF-7 和/或 MDA-MB-231 影响的英文文章均符合本综述的条件。共有 31 篇文章被纳入本综述。其中，23 项研究调查了 QT 对 MCF-7 细胞的影响，表明 QT 诱导细胞凋亡。在 15 项研究 QT 对 MDA-MB-231 细胞影响的研究中，有 14 项报告显示凋亡成功。结论是 QT 可能有益于消除乳腺癌细胞。但是，需要进一步的临床试验来进一步验证这些结果。
