Berdicevsky I, Grossowicz N
J Gen Microbiol. 1977 Oct;102(2):299-304. doi: 10.1099/00221287-102-2-299.
The polyene antibiotic, amphotericin, inhibited phosphate uptake in Candida albicans more strongly than it inhibited growth. Cultures grown from an inoculum of young (2 h) cells were more affected than those inoculated with old (24 h) cells. Thus, the polyene displays a double effect on C. albicans (and presumably on other eukaryotic cells): it interferes with membrane sterols and also inhibits synthesis of a factor (or factors) during growth. Whether this factor(s) interferes with the uptake of the polyene antibiotic or neutralizes its effect by reacting with it remains unsolved.
多烯抗生素两性霉素对白色念珠菌磷酸盐摄取的抑制作用比对其生长的抑制作用更强。用年轻（2小时）细胞接种培养的培养物比用年老（24小时）细胞接种的培养物受到的影响更大。因此，多烯对白色念珠菌（可能对其他真核细胞也一样）具有双重作用：它干扰膜甾醇，并且在生长过程中抑制一种或多种因子的合成。这种因子是否干扰多烯抗生素的摄取或通过与之反应来中和其作用仍未解决。
