Laval University, Cardiac Surgery Department, Institut Universitaire de Cardiologie et de Pneumologie de Québec (IUCPQ), Quebec City, Canada.
Héma-Québec, Côte-Vertu Ouest, Saint-Laurent, Canada.
J Vasc Surg. 2021 Sep;74(3):972-978. doi: 10.1016/j.jvs.2021.02.022. Epub 2021 Mar 5.
In Canada, tissue distribution is managed by provincial entities. In 2014, Hema-Quebec established a cryopreserved vascular tissue bank accessible to all Canadian hospitals. The objectives of this report were to review the first 5 years of activity of Hema-Quebec's vascular bank and to briefly assess the competitiveness of its products.
Deceased donors, ages 15 to 60, were screened for common blood-borne diseases. Grafts were treated in a triple-antibiotic solution at 35°C before preservation at -100°C. Hema-Quebec's vascular graft records were analyzed from 2014 to 2019 inclusively.
The average donor age was 35 years old and 78% of donors were men. Overall, 63% of harvested grafts cleared the quality management system. Positive microbial cultures and morphologic defects were the major reasons for graft discard. As such, a total of 60 grafts were delivered between 2016 and 2019 to 8 hospital centers. Moreover, the bank achieved a mean activity increase of 55% per year and Hema-Quebec's homografts were 48% less costly compared with similar homographs from for-profit organizations.
Our findings demonstrate that Hema-Quebec has established a viable cryopreserved vascular tissue bank with steady increase in activity and an acceptable graft discard rates and pricing. Based on our findings, we recommend that efforts should be directed to expand the tissue bank graft distribution outside the province of Quebec.
在加拿大，组织分配由省级实体管理。2014 年，魁北克血液服务中心建立了一个可供所有加拿大医院使用的冷冻血管组织库。本报告的目的是回顾魁北克血液服务中心血管库的前 5 年活动，并简要评估其产品的竞争力。
对年龄在 15 至 60 岁之间的已故供体进行常见血液传播疾病筛查。移植物在 35°C 的三联抗生素溶液中处理，然后在-100°C 下保存。对 2014 年至 2019 年期间魁北克血液服务中心血管移植物的记录进行了分析。
供体的平均年龄为 35 岁，78%的供体为男性。总体而言，63%的收获移植物通过质量管理体系。阳性微生物培养和形态缺陷是移植物报废的主要原因。因此，2016 年至 2019 年期间，共有 60 个移植物交付给 8 个医院中心。此外，该库的年平均活动增长率为 55%，与营利性组织的类似同种移植物相比，魁北克血液服务中心的同种移植物成本降低了 48%。
我们的研究结果表明，魁北克血液服务中心已经建立了一个可行的冷冻血管组织库，其活动稳步增加，移植物报废率和价格可接受。基于我们的发现，我们建议应努力扩大组织库移植物在魁北克省以外的分配。
