Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise G. Caporale, 64100, Teramo, Italy.
Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise G. Caporale, 64100, Teramo, Italy.
Int J Infect Dis. 2021 Apr;105:753-755. doi: 10.1016/j.ijid.2021.03.005. Epub 2021 Mar 5.
Following the announcement on December 2020 about the emergence of a new variant (VOC 202012/ 01, B.1.1.7 lineage) in the United Kingdom, a targeted surveillance was put in place in the Abruzzo region (Italy), which allowed detection of 313 persons affected by lineage B.1.1.7, up to the 20th of February 2021. We investigated the results of RT-PCR on nasopharyngeal swabs tested from December 2020 to February 2021 to verify any difference on the viral load and persistence between people infected by lineage B.1.1.7 and others. Statistically significant lower values of CT associated with the detection of the N protein encoding gene (CT N) were observed in persons with lineage B.1.1.7 infection (median CT N = 15.8)in comparison to those infected by other lineages (median CT N = 16.9). A significantly longer duration of the persistence of SARS-CoV-2 RNA in nasopharyngeal swabs was observed in persons with lineage B.1.1.7 infection (16 days) in comparison to those infected by other lineages (14 days).
2020 年 12 月英国宣布出现一种新型变异病毒(VOC 202012/01,B.1.1.7 谱系)后,阿布鲁佐地区(意大利)开始进行有针对性的监测,截至 2021 年 2 月 20 日,共发现 313 例 B.1.1.7 谱系感染者。我们调查了 2020 年 12 月至 2021 年 2 月期间鼻咽拭子 RT-PCR 的检测结果,以验证 B.1.1.7 谱系感染者与其他感染者之间病毒载量和持续时间是否存在差异。与其他谱系感染者相比,B.1.1.7 谱系感染者的 N 蛋白编码基因(CTN)检测的 CT 值明显较低(中位 CTN=15.8)。B.1.1.7 谱系感染者鼻咽拭子中 SARS-CoV-2 RNA 的持续时间明显较长(16 天),而其他谱系感染者为 14 天。