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机器人辅助全膝关节置换术是否具有成本效益?一种马尔可夫决策分析。

Can robot-assisted total knee arthroplasty be a cost-effective procedure? A Markov decision analysis.

机构信息

Department of Orthopedic Surgery, Ghent University Hospital, C. Heymanslaan 10, 9000 Gent, Belgium.

Department of Orthopedic Surgery, Ghent University Hospital, C. Heymanslaan 10, 9000 Gent, Belgium; Innovation, Entrepreneurship and Service Management, Ghent University, Tweekerkenstraat 2, 9000 Gent, Belgium.

出版信息

Knee. 2021 Mar;29:345-352. doi: 10.1016/j.knee.2021.02.004. Epub 2021 Mar 6.

Abstract

BACKGROUND

Total knee arthroplasty (TKA) is a frequently and increasingly performed surgery in the treatment of disabling knee osteoarthritis. The rising number of procedures and related revisions pose an increasing economic burden on health care systems. In an attempt to lower the revision rate due to component malalignment and soft tissue imbalance in TKA, robotic assistance (RA) has been introduced in the operating theatre. The primary objective of this study is to provide the results of a theoretical, preliminary cost-effectiveness analysis of RA TKA.

METHODS

A Markov state-transition model was designed to model the health status of sixty-seven-year-old patients in need of TKA due to primary osteoarthritis over a twenty-year period following their knee joint replacement. Transitional probabilities and independent variables were extracted from existing literature.

RESULTS

The value attributed to the utility both for primary and revision surgery has the biggest impact on the ICER, followed by the rate of successful primary surgery and the cost of RA-technology. Only 2.18% of the samples yielded from the probabilistic sensitivity analysis proved to be cost-effective (threshold set at $50000/QALY). A calculated surgical volume of at least 253 cases per robot per year is needed to prove cost-effective taking the predetermined parameter values into account.

CONCLUSION

Based upon transitional probabilities and independent variables derived from existing studies, RA TKA may be cost-effective at a surgical volume of 253 cases per robot per year when compared to conventional TKA.

摘要

背景

全膝关节置换术(TKA)是治疗致残性膝骨关节炎的常用且日益增多的手术。手术数量的增加以及相关的翻修给医疗保健系统带来了越来越大的经济负担。为了降低 TKA 中因组件对线不良和软组织失衡导致的翻修率,机器人辅助(RA)已在手术室中引入。本研究的主要目的是提供 RA-TKA 的理论性、初步成本效益分析结果。

方法

设计了一个马尔可夫状态转移模型,以在接受 TKA 的 67 岁患者的膝关节置换后 20 年内,对原发性骨关节炎患者的健康状况进行建模。转移概率和自变量均从现有文献中提取。

结果

初级手术和翻修手术的效用值对 ICER 的影响最大,其次是初级手术的成功率和 RA 技术的成本。只有概率敏感性分析产生的 2.18%的样本被证明是具有成本效益的(阈值设定为 50000 美元/QALY)。考虑到预定的参数值,需要至少每年每台机器人 253 例手术才能证明具有成本效益。

结论

基于从现有研究中得出的转移概率和自变量,与传统 TKA 相比,当每台机器人每年进行 253 例手术时,RA-TKA 可能具有成本效益。

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