Mengs U
Department of Toxicology and Experimental Pathology, Dr. Madaus GmbH & Co., Cologne, FRG.
Pharmacology. 1988;36 Suppl 1:180-7. doi: 10.1159/000138438.
Sennosides were tested in a wide range of toxicity studies to evaluate risk assessment. From acute studies, sennosides could be classified as only slightly toxic in rats and mice after a single oral dose. The LD50 values were about 5,000 mg/kg in both species. The cause of death was probably due to an extensive loss of water and electrolytes following massive diarrhoea. In subacute studies with rats (max. 20 mg/kg) and dogs (max. 500 mg/kg), sennosides caused no specific local or systemic toxicity. Minor increase in kidney weight in rats was toxicologically not relevant. In a 6-month study with rats, sennosides were tolerated without specific toxic effects in doses up to 100 mg/kg. Effects on food consumption, body weight gain and some biochemical parameters as well as slight renal lesions can be interpreted as secondary effects following chronic diarrhoea. Mutagenicity tests and reproduction toxicity studies showed no abnormal results.
番泻苷在广泛的毒性研究中进行了测试，以评估风险评估。从急性研究来看，番泻苷在大鼠和小鼠单次口服给药后仅被归类为低毒。两种物种的半数致死量（LD50）值约为5000毫克/千克。死亡原因可能是大量腹泻后水分和电解质的大量流失。在对大鼠（最大剂量20毫克/千克）和狗（最大剂量500毫克/千克）进行的亚急性研究中，番泻苷未引起特定的局部或全身毒性。大鼠肾脏重量的轻微增加在毒理学上不相关。在对大鼠进行的为期6个月的研究中，番泻苷在高达100毫克/千克的剂量下耐受性良好，无特定毒性作用。对食物消耗、体重增加和一些生化参数的影响以及轻微的肾脏病变可解释为慢性腹泻后的继发效应。致突变性试验和生殖毒性研究均未显示异常结果。
