Hietala P, Marvola M, Parviainen T, Lainonen H
Extracta Ltd., Helsinki, Finland.
Pharmacol Toxicol. 1987 Aug;61(2):153-6. doi: 10.1111/j.1600-0773.1987.tb01794.x.
This paper investigates the laxative effect and acute toxicity of certain fractions of senna extracts in mice. The same tests were also carried out with several pure anthraquinone derivatives common in senna pods. The results show that the laxative and toxic components of senna pods and senna extracts can be separated. The most potent laxative components, sennosides A + B and Fraction V (relative potencies 1 and 0.9 respectively), have the lowest toxicity (relative intravenous toxicities 1 and less than 1). Fractions with very low laxative activity (rhein-8-glucoside and Fraction IV, relative potencies 0.56 and 0.05) have the highest acute toxicity (relative toxicities 10 and 32 respectively).
本文研究了番泻叶提取物某些组分对小鼠的泻下作用和急性毒性。还对番泻叶荚中几种常见的纯蒽醌衍生物进行了相同的试验。结果表明，番泻叶荚和番泻叶提取物的泻下成分和毒性成分可以分离。最强效的泻下成分番泻苷A + B和组分V（相对效价分别为1和0.9）具有最低的毒性（相对静脉毒性分别为1和小于1）。泻下活性非常低的组分（大黄酸-8-葡萄糖苷和组分IV，相对效价分别为0.56和0.05）具有最高的急性毒性（相对毒性分别为10和32）。
