反对番泻叶效应依赖前列腺素形成的证据。

Evidence against a dependence of the senna effect on prostaglandin formation.

作者信息

Mascolo N, Meli R, Autore G, Capasso F

机构信息

Department of Experimental Pharmacology, University of Naples, Italy.

出版信息

Pharmacology. 1988;36 Suppl 1:92-7. doi: 10.1159/000138426.

DOI:10.1159/000138426

PMID:3368528

Abstract

The laxation induced by senna is not modified in rats either maintained on a diet deficient in essential fatty acids (EFAD) or exposed to cold (6 degrees C) or with yeast-induced fever. In light of our findings it appears conceivable that non-PG-mediated mechanism(s) play a relevant role in laxation induced by senna.

摘要

在食用缺乏必需脂肪酸（EFAD）的饮食、暴露于寒冷环境（6摄氏度）或酵母诱导发热的大鼠中，番泻叶引起的腹泻没有改变。根据我们的研究结果，似乎可以想象非前列腺素介导的机制在番泻叶引起的腹泻中起相关作用。